Synthesis, characterization and antimicrobial activity of copper and zinc-doped hydroxyapatite nanopowders

被引：439

作者：

Stanic, Vojislav ^{[1
]}

Dimitrijevic, Suzana ^{[2
]}

Antic-Stankovic, Jelena ^{[3
]}

Mitric, Miodrag ^{[1
]}

Jokic, Bojan ^{[2
]}

Plecas, Ilija B. ^{[1
]}

Raicevic, Slavica ^{[1
]}

机构：

[1] Univ Belgrade, Vinca Inst Nucl Sci, Belgrade 11001, Serbia

[2] Univ Belgrade, Fac Technol & Met, Belgrade 11001, Serbia

[3] Univ Belgrade, Fac Pharm, Belgrade 11001, Serbia

来源：

APPLIED SURFACE SCIENCE | 2010年 / 256卷 / 20期

关键词：

Hydroxyapatite; Cu; Zn; Nanoparticle; Antimicrobial; CALCIUM PHOSPHATES; ANTIBACTERIAL; HYDROXYLAPATITE; TEMPERATURE; INHIBITION; CADMIUM; IONS;

D O I：

10.1016/j.apsusc.2010.03.124

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Antimicrobial materials based on hydroxyapatite are potentially attractive in a wide variety of medical applications. The synthesis of copper and zinc-doped hydroxyapatite was done by neutralization method. This method consists of dissolving CuO or ZnO in solution of H3PO4, and the slow addition to suspension of Ca(OH)(2) for obtaining monophasic product. Characterization studies from XRD, SEM, TEM and FTIR spectra showed that particles of all samples are of nano size and they do not contain any discernible crystalline impurity. The quantitative elemental analysis showed that the copper and zinc ions fully incorporated into the hydroxyapatite. The antimicrobial effects of doped hydroxyapatite powders against pathogen bacterial strains Escherichia coli, Staphylococcus aureus and pathogen yeast Candida albicans were tested in solid and liquid media. Quantitative test in liquid media clearly showed that copper and zinc-doped samples had viable cells reduction ability for all tested strains. (C) 2010 Elsevier B. V. All rights reserved.

引用

页码：6083 / 6089

页数：7

共 39 条

[1] Hydroxyapatite adherence as a means to concentrate bacteria
Berry, ED
Siragusa, GR
[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1997, 63 (10) : 4069 - 4074
[2] INHIBITING EFFECT OF ZINC ON HYDROXYLAPATITE CRYSTALLIZATION
BIGI, A
FORESTI, E
GANDOLFI, M
GAZZANO, M
ROVERI, N
[J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 1995, 58 (01) : 49 - 58
[3] Copper as a biocidal tool
Borkow, G
Gabbay, J
[J]. CURRENT MEDICINAL CHEMISTRY, 2005, 12 (18) : 2163 - 2175
[4] The significance of infection related to orthopedic devices and issues of antibiotic resistance
Campoccia, D
Montanaro, L
Arciola, CR
[J]. BIOMATERIALS, 2006, 27 (11) : 2331 - 2339
[5] In vitro susceptibility of methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus to a new antimicrobial, copper silicate
Carson, Kerry C.
Bartlett, Jessica G.
Tan, Trina-Jean
Riley, Thomas V.
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (12) : 4505 - 4507
[6] In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating
Chen, W.
Liu, Y.
Courtney, H. S.
Bettenga, M.
Agrawal, C. M.
Bumgardner, J. D.
Ong, J. L.
[J]. BIOMATERIALS, 2006, 27 (32) : 5512 - 5517
[7] Antimicrobial effects and human gingival biocompatibility of hydroxyapatite sol-gel coatings
Chung, RJ
Hsieh, MF
Huang, CW
Perng, LH
Wen, HW
Chin, TS
[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2006, 76B (01) : 169 - 178
[8] Anti-microbial hydroxyapatite particles synthesized by a sol-gel route
Chung, RJ
Hsieh, MF
Huang, KC
Perng, LH
Chou, FI
Chin, TS
[J]. JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, 2005, 33 (02) : 229 - 239
[9] Preparation, characterization and antibacterial properties against E-coli K88 of chitosan nanoparticle loaded copper ions
Du, Wen-Li
Xu, Ying-Lei
Xu, Zi-Rong
Fan, Cheng-Li
[J]. NANOTECHNOLOGY, 2008, 19 (08)
[10] Hydroxylapatite with substituted magnesium, zinc, cadmium, and yttrium. I. Structure and microstructure
Ergun, C
Webster, TJ
Bizios, R
Doremus, RH
[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 59 (02): : 305 - 311

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