Water extract of onion peel for the synthesis of bisindolylmethanes

被引:21
作者
Chia, Poh Wai [1 ,2 ]
Lim, Ban Soon [1 ]
Tan, Khai Chen [1 ]
Yong, Fu Siong Julius [2 ]
Kan, Su-Yin [3 ]
机构
[1] Univ Malaysia Terengganu, Sch Marine & Environm Sci, Terengganu, Malaysia
[2] Univ Malaysia Terengganu, Inst Marine Biotechnol, Terengganu, Malaysia
[3] Univ Sultan Zainal Abidin, Fac Hlth Sci, Terengganu 21300, Malaysia
关键词
Water extract of onion peel; Bisindolylmethanes; Green and recyclable protocol; Heterocyclic compounds; BISINDOLE ALKALOIDS; WASTE; BIS(INDOLYL)METHANES; EFFICIENT; CATALYST; PRODUCTS; SOLVENT; SYSTEMS;
D O I
10.1016/j.jksus.2018.05.029
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
An efficient catalytic system for the synthesis of bisindolylmethanes (BIMs) using Water Extract of Onion Peel (WEOP) is described in this study. The advantages of this protocol include avoid the use of acids and bases, reusability of the WEOP catalytic system, good to excellent yield and reduce the use of toxic reagents. This is the first report of using WEOP catalytic system in the preparation of BIMs. We anticipate the method presented here will find great utility in the field of synthetic chemistry and the synthesis of other heterocyclic compounds in the near future. (C) 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码:642 / 647
页数:6
相关论文
共 38 条
[1]   Green procedure for the synthesis of bis(indolyl)methanes in water [J].
Azizi, N. ;
Gholibeghlo, E. ;
Manocheri, Z. .
SCIENTIA IRANICA, 2012, 19 (03) :574-578
[2]  
Benkeblia N., 2007, RES REV BIOSCI, V1, P135
[3]   Discovery of 3,3′-diindolylmethanes as potent antileishmanial agents [J].
Bharate, Sandip B. ;
Bharate, Jaideep B. ;
Khan, Shabana I. ;
Tekwani, Babu L. ;
Jacob, Melissa R. ;
Mudududdla, Ramesh ;
Yadav, Rammohan R. ;
Singh, Baljinder ;
Sharma, P. R. ;
Maity, Sudip ;
Singh, Baldev ;
Khan, Ikhlas A. ;
Vishwakarma, Ram A. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 63 :435-443
[4]   Water: the most versatile and nature's friendly media in asymmetric organocatalyzed direct aldol reactions [J].
Bhowmick, Sudipto ;
Mondal, Anirban ;
Ghosh, Ayndrila ;
Bhowmick, Kartick C. .
TETRAHEDRON-ASYMMETRY, 2015, 26 (21-22) :1215-1244
[5]   Isolation of colour components from native dye-bearing plants in northeastern India [J].
Bhuyan, R ;
Saikia, CN .
BIORESOURCE TECHNOLOGY, 2005, 96 (03) :363-372
[6]   Pd(OAc)2 in WERSA: a novel green catalytic system for Suzuki-Miyaura cross-coupling reactions at room temperature [J].
Boruah, Preeti Rekha ;
Ali, Abdul Aziz ;
Chetia, Mitali ;
Saikia, Bishwajit ;
Sarma, Diganta .
CHEMICAL COMMUNICATIONS, 2015, 51 (57) :11489-11492
[7]   Onion skin waste as a valorization resource for the by-products quercetin and biosugar [J].
Choi, In Seong ;
Cho, Eun Jin ;
Moon, Jae-Hak ;
Bae, Hyeun-Jong .
FOOD CHEMISTRY, 2015, 188 :537-542
[8]   A green protocol for ligand, copper and base free Sonogashira cross-coupling reaction [J].
Dewan, Anindita ;
Sarmah, Manashi ;
Bora, Utpal ;
Thakur, Ashim J. .
TETRAHEDRON LETTERS, 2016, 57 (33) :3760-3763
[9]  
El-Sayed M., 2014, CURR CHEM LETT, V3, P7, DOI [10.5267/j.ccl.2013.10.003, DOI 10.5267/J.CCL.2013.10.003]
[10]   Direct enantioselective aldol reactions catalyzed by calix[4]arene-based L-proline derivatives in the water [J].
Eymur, Serkan ;
Akceylan, Ezgi ;
Sahin, Ozlem ;
Uyanik, Arzu ;
Yilmaz, Mustafa .
TETRAHEDRON, 2014, 70 (30) :4471-4477