Design and synthesis of a transition state analog of a metalloporphyrin-catalysed oxidation reaction

被引：1
|
作者：
Giger, R
Hoffmann, P
机构：
[1] Univ Toulouse 3, LSPCMIB, F-31062 Toulouse 4, France
[2] Novartis Pharma AG, CH-4002 Basel, Switzerland
来源：
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES | 2002年 / 6卷 / 05期
关键词：
catalytic antibodies; transition state analog; cyclosporin;
D O I：
10.1142/S1088424602000439
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A hapten that mimics the transition state of a metalloporphyrin-catalysed oxidation reaction was synthesized in order to generate antibodies that might be able to catalyse the regioselective metalloporphyrin-co-catalysed reaction of cyclosporin A to [D-Ser(8)]cyclosporin A. Copyright (C) 2002 Society of Porphyrins & Phthalocyanines.
引用
收藏
页码：362 / 365
页数：4
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