κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus

被引：68

作者：

Freudenthal, R ^{[1
]}

Locatelli, F ^{[1
]}

Hermitte, G ^{[1
]}

Maldonado, H ^{[1
]}

Lafourcade, C ^{[1
]}

Delorenzi, A ^{[1
]}

Romano, A ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Lab Neurobiol Memoria, Dept Ciencias Biol, RA-1428 Buenos Aires, DF, Argentina

来源：

NEUROSCIENCE LETTERS | 1998年 / 242卷 / 03期

关键词：

long-term memory; transcription factors; Rel/NF kappa-B; Dorsal/Dif; gel shift; crab; habituation;

D O I：

10.1016/S0304-3940(98)00059-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/NF kappa-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/kappa-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/kappa-B like DNA-binding activity in the brain is specifically related to LTH formation. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：143 / 146

页数：4

共 21 条

[1] C/EBP IS AN IMMEDIATE-EARLY GENE REQUIRED FOR THE CONSOLIDATION OF LONG-TERM FACILITATION IN APLYSIA [J].