Migraine Does Not Affect Cognitive Decline: Results From the Maastricht Aging Study

被引：52
作者：
Baars, Maria A. E. [1 ]
van Boxtel, Martin P. J. [1 ]
Jolles, Jelle [1 ]
机构：
[1] Maastricht Univ, Sch Mental Hlth & Neurosci, Div Brain & Cognit, Fac Hlth Med & Life Sci, NL-6200 MD Maastricht, Netherlands
来源：
HEADACHE | 2010年 / 50卷 / 02期
关键词：
migraine; cognitive performance decline; medication use; memory; executive functioning; PARTICIPANTS AGED 24-81; WHITE-MATTER LESIONS; NORMATIVE DATA; RISK; SEX; EDUCATION; INFARCTS; HEALTH; MAAS; POPULATION;
D O I：
10.1111/j.1526-4610.2009.01572.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective.-To investigate the effects of migraine and related pharmacotherapy on cognitive performance and cognitive change over time in a longitudinal population-based study. Methods.-Migraineurs (n = 99) and healthy controls (n = 1724) participating in the Maastricht Aging Study were cognitively tested at baseline and after 6 years. Scores on Mini Mental State Examination, immediate and delayed recall tests, and tests for simple and complex speed were compared for both groups. Generalized Estimating Equations analyses were performed to test the longitudinal effects of migraines on cognition. Effects of migraine medication use were also tested. Results.-Migraine headaches were found to have no effect on any of the cognitive measures. Medication use also had no effect on all cognitive measures. Conclusions.-No evidence was found that migraine headaches or migraine-related medication use are risk or protective factors for cognitive dysfunction or cognitive deterioration over time.
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页码：176 / 184
页数：9
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