Small airway segmentation in thoracic computed tomography scans: a machine learning approach

被引:14
作者
Bian, Z. [1 ,2 ]
Charbonnier, J-P [1 ]
Liu, J. [2 ]
Zhao, D. [2 ]
Lynch, D. A. [3 ]
van Ginneken, B. [1 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Radiol & Nucl Med, Diagnost Image Anal Grp, Nijmegen, Netherlands
[2] Northeastern Univ, Minist Educ, Key Lab Med Image Comp, Shenyang, Liaoning, Peoples R China
[3] Natl Jewish Hlth, Dept Radiol, Denver, CO USA
基金
中国国家自然科学基金;
关键词
computed tomography; small airways; machine learning; sampling; tubular features; texture features; RAY CT IMAGES; TREE; EXTRACTION; CLASSIFICATION; EMPHYSEMA; DISEASES; COPD;
D O I
10.1088/1361-6560/aad2a1
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Small airway obstruction is a main cause for chronic obstructive pulmonary disease (COPD). We propose a novel method based on machine learning to extract the airway system from a thoracic computed tomography (CT) scan. The emphasis of the proposed method is on including the smallest airways that are still visible on CT. We used an optimized sampling procedure to extract airway and non-airway voxel samples from a large set of scans for which a semi-automatically constructed reference standard was available. We created a set of features which represent tubular and texture properties that are characteristic for small airway voxels. A random forest classifier was used to determine for each voxel if it belongs to the airway class. Our method was validated on a set of 20 clinical thoracic CT scans from the COPDGene study. Experiments show that our method is effective in extracting the full airway system and in detecting a large number of small airways that were missed by the semi-automatically constructed reference standard.
引用
收藏
页数:14
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