Femtosecond laser fabricated monolithic chip for optical trapping and stretching of single cells

被引：127

作者：

Bellini, N. ^{[1
,2
]}

Vishnubhatla, K. C. ^{[1
,2
]}

Bragheri, F. ^{[3
,4
]}

Ferrara, L. ^{[3
,4
]}

Minzioni, P. ^{[3
,4
]}

Ramponi, R. ^{[1
,2
]}

Cristiani, I. ^{[3
,4
]}

Osellame, R. ^{[1
,2
]}

机构：

[1] Politecn Milan, CNR, IFN, I-20133 Milan, Italy

[2] Politecn Milan, Dipartimento Fis, I-20133 Milan, Italy

[3] Univ Pavia, CNISM, I-27100 Pavia, Italy

[4] Univ Pavia, Dipartimento Elettron, I-27100 Pavia, Italy

来源：

OPTICS EXPRESS | 2010年 / 18卷 / 05期

关键词：

FUSED-SILICA; INTEGRATION; PULSES; SYSTEM;

D O I：

10.1364/OE.18.004679

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We report on the fabrication by a femtosecond laser of an optofluidic device for optical trapping and stretching of single cells. Versatility and three-dimensional capabilities of this fabrication technology provide straightforward and extremely accurate alignment between the optical and fluidic components. Optical trapping and stretching of single red blood cells are demonstrated, thus proving the effectiveness of the proposed device as a monolithic optical stretcher. Our results pave the way for a new class of optofluidic devices for single cell analysis, in which, taking advantage of the flexibility of femtosecond laser micromachining, it is possible to further integrate sensing and sorting functions. (C) 2010 Optical Society of America

引用

页码：4679 / 4688

页数：10

共 24 条

[11] Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence
Guck, J
Schinkinger, S
Lincoln, B
Wottawah, F
Ebert, S
Romeyke, M
Lenz, D
Erickson, HM
Ananthakrishnan, R
Mitchell, D
Käs, J
Ulvick, S
Bilby, C
[J]. BIOPHYSICAL JOURNAL, 2005, 88 (05) : 3689 - 3698
[12] Nano-aquarium with microfluidic structures for dynamic analysis of Cryptomonas and Phormidium fabricated by femtosecond laser direct writing of photostructurable glass
Hanada, Yasutaka
Sugioka, Koji
Kawano, Hiroyuki
Ishikawa, Ikuko Shihira
Miyawaki, Atsushi
Midorikawa, Katsumi
[J]. APPLIED SURFACE SCIENCE, 2009, 255 (24) : 9893 - 9897
[13] Single cell detection using a glass-based optofluidic device fabricated by femtosecond laser pulses
Kim, Moosung
Hwang, David J.
Jeon, Hojeong
Hiromatsu, Kuniaki
Grigoropoulos, Costas P.
[J]. LAB ON A CHIP, 2009, 9 (02) : 311 - 318
[14] Miniaturized all-fibre probe for three-dimensional optical trapping and manipulation
Liberale, Carlo
Minzioni, Paolo
Bragheri, Francesca
De Angelis, Francesco
Di Fabrizio, Enzo
Cristiani, Ilaria
[J]. NATURE PHOTONICS, 2007, 1 (12) : 723 - 727
[15] Reconfigurable microfluidic integration of a dual-beam laser trap with biomedical applications
Lincoln, Bryan
Schinkinger, Stefan
Travis, Kort
Wottawah, Falk
Ebert, Susanne
Sauer, Frank
Guck, Jochen
[J]. BIOMEDICAL MICRODEVICES, 2007, 9 (05) : 703 - 710
[16] Femtosecond laser-assisted three-dimensional microfabrication in silica
Marcinkevicius, A
Juodkazis, S
Watanabe, M
Miwa, M
Matsuo, S
Misawa, H
Nishii, J
[J]. OPTICS LETTERS, 2001, 26 (05) : 277 - 279
[17] Fabrication of long microchannels with circular cross section using astigmatically shaped femtosecond laser pulses and chemical etching
Maselli, Valeria
Osellame, Roberto
Cerullo, Giulio
Ramponi, Roberta
Laporta, Paolo
Magagnin, Luca
Cavallotti, Pietro Luigi
[J]. APPLIED PHYSICS LETTERS, 2006, 88 (19)
[18] Femtosecond laser written optofluidic sensor: Bragg grating waveguide evanescent probing of microfluidic channel
Maselli, Valeria
Grenier, Jason R.
Ho, Stephen
Herman, Peter R.
[J]. OPTICS EXPRESS, 2009, 17 (14): : 11719 - 11729
[19] Lights, action: optical tweezers
Molloy, JE
Padgett, MJ
[J]. CONTEMPORARY PHYSICS, 2002, 43 (04) : 241 - 258
[20] Integration of optical waveguides and microfluidic channels both fabricated by femtosecond laser irradiation
Osellame, Roberto
Maselli, Valeria
Vazquez, Rebeca Martinez
Ramponi, Roberta
Cerullo, Giulio
[J]. APPLIED PHYSICS LETTERS, 2007, 90 (23)

← 1 2 3 →