Femtosecond laser fabricated monolithic chip for optical trapping and stretching of single cells

被引：127
作者：
Bellini, N. [1 ,2 ]
Vishnubhatla, K. C. [1 ,2 ]
Bragheri, F. [3 ,4 ]
Ferrara, L. [3 ,4 ]
Minzioni, P. [3 ,4 ]
Ramponi, R. [1 ,2 ]
Cristiani, I. [3 ,4 ]
Osellame, R. [1 ,2 ]
机构：
[1] Politecn Milan, CNR, IFN, I-20133 Milan, Italy
[2] Politecn Milan, Dipartimento Fis, I-20133 Milan, Italy
[3] Univ Pavia, CNISM, I-27100 Pavia, Italy
[4] Univ Pavia, Dipartimento Elettron, I-27100 Pavia, Italy
来源：
OPTICS EXPRESS | 2010年 / 18卷 / 05期
关键词：
FUSED-SILICA; INTEGRATION; PULSES; SYSTEM;
D O I：
10.1364/OE.18.004679
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We report on the fabrication by a femtosecond laser of an optofluidic device for optical trapping and stretching of single cells. Versatility and three-dimensional capabilities of this fabrication technology provide straightforward and extremely accurate alignment between the optical and fluidic components. Optical trapping and stretching of single red blood cells are demonstrated, thus proving the effectiveness of the proposed device as a monolithic optical stretcher. Our results pave the way for a new class of optofluidic devices for single cell analysis, in which, taking advantage of the flexibility of femtosecond laser micromachining, it is possible to further integrate sensing and sorting functions. (C) 2010 Optical Society of America
引用
收藏
页码：4679 / 4688
页数：10
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