Femtosecond laser fabricated monolithic chip for optical trapping and stretching of single cells

被引：127
作者：
Bellini, N. [1 ,2 ]
Vishnubhatla, K. C. [1 ,2 ]
Bragheri, F. [3 ,4 ]
Ferrara, L. [3 ,4 ]
Minzioni, P. [3 ,4 ]
Ramponi, R. [1 ,2 ]
Cristiani, I. [3 ,4 ]
Osellame, R. [1 ,2 ]
机构：
[1] Politecn Milan, CNR, IFN, I-20133 Milan, Italy
[2] Politecn Milan, Dipartimento Fis, I-20133 Milan, Italy
[3] Univ Pavia, CNISM, I-27100 Pavia, Italy
[4] Univ Pavia, Dipartimento Elettron, I-27100 Pavia, Italy
来源：
OPTICS EXPRESS | 2010年 / 18卷 / 05期
关键词：
FUSED-SILICA; INTEGRATION; PULSES; SYSTEM;
D O I：
10.1364/OE.18.004679
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We report on the fabrication by a femtosecond laser of an optofluidic device for optical trapping and stretching of single cells. Versatility and three-dimensional capabilities of this fabrication technology provide straightforward and extremely accurate alignment between the optical and fluidic components. Optical trapping and stretching of single red blood cells are demonstrated, thus proving the effectiveness of the proposed device as a monolithic optical stretcher. Our results pave the way for a new class of optofluidic devices for single cell analysis, in which, taking advantage of the flexibility of femtosecond laser micromachining, it is possible to further integrate sensing and sorting functions. (C) 2010 Optical Society of America
引用
收藏
页码：4679 / 4688
页数：10
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共 24 条
  • [1] Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping
    Applegate, RW
    Squier, J
    Vestad, T
    Oakey, J
    Marr, DWM
    Bado, P
    Dugan, MA
    Said, AA
    [J]. LAB ON A CHIP, 2006, 6 (03) : 422 - 426
  • [2] ACCELERATION AND TRAPPING OF PARTICLES BY RADIATION PRESSURE
    ASHKIN, A
    [J]. PHYSICAL REVIEW LETTERS, 1970, 24 (04) : 156 - &
  • [3] Fabrication of high-aspect ratio, micro-fluidic channels and tunnels using femtosecond laser pulses and chemical etching
    Bellouard, Y
    Said, A
    Dugan, M
    Bado, P
    [J]. OPTICS EXPRESS, 2004, 12 (10): : 2120 - 2129
  • [4] DEMONSTRATION OF A FIBEROPTIC LIGHT-FORCE TRAP
    CONSTABLE, A
    KIM, J
    MERVIS, J
    ZARINETCHI, F
    PRENTISS, M
    [J]. OPTICS LETTERS, 1993, 18 (21) : 1867 - 1869
  • [5] Integrated monolithic optical manipulation
    Cran-McGreehin, Simon
    Krauss, Thomas F.
    Dholakia, Kishan
    [J]. LAB ON A CHIP, 2006, 6 (09) : 1122 - 1124
  • [6] Micromachining of photonic devices by femtosecond laser pulses
    Della Valle, G.
    Osellame, R.
    Laporta, P.
    [J]. JOURNAL OF OPTICS A-PURE AND APPLIED OPTICS, 2009, 11 (01):
  • [7] The microscopy cell (MicCell), a versatile modular flowthrough system for cell biology, biomaterial research, and nanotechnology
    Gast, FU
    Dittrich, PS
    Schwille, P
    Weigel, M
    Mertig, M
    Opitz, J
    Queitsch, U
    Diez, S
    Lincoln, B
    Wottawah, F
    Schinkinger, S
    Guck, J
    Käs, J
    Smolinski, J
    Salchert, K
    Werner, C
    Duschl, C
    Jäger, MS
    Uhlig, K
    Geggier, P
    Howitz, S
    [J]. MICROFLUIDICS AND NANOFLUIDICS, 2006, 2 (01) : 21 - 36
  • [8] Femtosecond laser micromachining in transparent materials
    Gattass, Rafael R.
    Mazur, Eric
    [J]. NATURE PHOTONICS, 2008, 2 (04) : 219 - 225
  • [9] A revolution in optical manipulation
    Grier, DG
    [J]. NATURE, 2003, 424 (6950) : 810 - 816
  • [10] The optical stretcher:: A novel laser tool to micromanipulate cells
    Guck, J
    Ananthakrishnan, R
    Mahmood, H
    Moon, TJ
    Cunningham, CC
    Käs, J
    [J]. BIOPHYSICAL JOURNAL, 2001, 81 (02) : 767 - 784
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