Investigating the Upstream and Downstream Hemodynamic Boundary Conditions of Healthy and Growth-Restricted Rat Feto-Placental Arterial Networks

被引:5
作者
Bappoo, Nikhilesh [1 ,2 ,3 ,4 ]
Kelsey, Lachlan J. [1 ,2 ,3 ]
Tongpob, Yutthapong [4 ,5 ]
Wyrwoll, Caitlin [4 ]
Doyle, Barry J. [1 ,2 ,3 ,6 ,7 ]
机构
[1] Univ Western Australia, QEII Med Ctr, Harry Perkins Inst Med Res, Vasc Engn Lab, Nedlands, WA 6009, Australia
[2] Univ Western Australia, UWA Ctr Med Res, Nedlands, WA 6009, Australia
[3] Univ Western Australia, Sch Engn, Perth, WA 6009, Australia
[4] Univ Western Australia, Sch Human Sci, Perth, WA 6009, Australia
[5] Naresuan Univ, Fac Med Sci, Phitsanulok, Thailand
[6] Australian Res Council, Ctr Personalised Therapeut Technol, Melbourne, Vic, Australia
[7] Univ Edinburgh, BHF Ctr Cardiovasc Sci, Edinburgh EH9 3FD, Midlothian, Scotland
基金
英国医学研究理事会;
关键词
Feto-placental; Vasculature; Computational fluid dynamics; Boundary conditions; Shear stress; BLOOD-FLOW; FETAL-GROWTH; COMPUTATIONAL ANALYSIS; LATE-GESTATION; VASCULATURE; TREE; TRANSPORT; PLACENTA; ORIGINS; WEIGHT;
D O I
10.1007/s10439-021-02749-4
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The placenta uniquely develops to orchestrate maternal adaptations and support fetal growth and development. The expansion of the feto-placental vascular network, in part, underpins function. However it is unclear how vascular development is synergistically influenced by hemodynamics and how impairment may lead to fetal growth restriction (FGR). Here, we present a robust framework consisting of ex vivo placental casting, imaging and computational fluid dynamics of rat feto-placental networks where we investigate inlet (steady and transient) and outlet (zero-pressure, Murray's Law, asymmetric fractal trees and porous blocks) boundary conditions in a model of growth-restriction. We show that the Murray's Law flow-split boundary condition is not always appropriate and that mean steady-state inlet conditions produce comparable results to transient flow. However, we conclude that transient simulations should be adopted as they provide a larger amount of valuable data, a necessity to bridge the current knowledge gap in placental biomechanics. We also show preliminary data on changes in flow, shear stress, and flow deceleration between control and growth-restricted feto-placental networks. Our proposed framework provides a standardized approach for structural and hemodynamic analysis of feto-placental vasculature and has the potential to enhance our understanding of placental function.
引用
收藏
页码:2183 / 2195
页数:13
相关论文
共 41 条
[1]  
[Anonymous], 2016, COMPUTATIONAL BIOMEC, DOI DOI 10.1364/BOE.7.004958
[2]   Diagnosis and Management of Fetal Growth Restriction [J].
Bamfo, Jacqueline E. A. K. ;
Odibo, Anthony O. .
JOURNAL OF PREGNANCY, 2011, 2011 :640715
[3]   Viscosity and haemodynamics in a late gestation rat feto-placental arterial network [J].
Bappoo, Nikhilesh ;
Kelsey, Lachlan J. ;
Parker, Louis ;
Crough, Tim ;
Moran, Carmel M. ;
Thomson, Adrian ;
Holmes, Megan C. ;
Wyrwoll, Caitlin S. ;
Doyle, Barry J. .
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 2017, 16 (04) :1361-1372
[4]   Regulation of vascular growth and function in the human placenta [J].
Burton, G. J. ;
Charnock-Jones, D. S. ;
Jauniaux, E. .
REPRODUCTION, 2009, 138 (06) :895-902
[5]   PLACENTAL ORIGINS OF CHRONIC DISEASE [J].
Burton, Graham J. ;
Fowden, Abigail L. ;
Thornburg, Kent L. .
PHYSIOLOGICAL REVIEWS, 2016, 96 (04) :1509-1565
[6]   The placenta: a multifaceted, transient organ [J].
Burton, Graham J. ;
Fowden, Abigail L. .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2015, 370 (1663)
[7]   Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections [J].
Cai, Ruiyao ;
Pan, Chenchen ;
Ghasemigharagoz, Alireza ;
Todorov, Mihail Ivilinov ;
Foerstera, Benjamin ;
Zhao, Shan ;
Bhatia, Harsharan S. ;
Parra-Damas, Arnaldo ;
Mrowka, Leander ;
Theodorou, Delphine ;
Rempfler, Markus ;
Xavier, Anna L. R. ;
Kress, Benjamin T. ;
Benakis, Corinne ;
Steinke, Hanno ;
Liebscher, Sabine ;
Bechmann, Ingo ;
Liesz, Arthur ;
Menze, Bjoern ;
Kerschensteiner, Martin ;
Nedergaard, Maiken ;
Ertuerk, Ali .
NATURE NEUROSCIENCE, 2019, 22 (02) :317-+
[8]   Procedure for estimation and reporting of uncertainty due to discretization in CFD applications [J].
Celik, Ishmail B. ;
Ghia, Urmila ;
Roache, Patrick J. ;
Freitas, Christopher J. .
JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, 2008, 130 (07) :0780011-0780014
[9]   Developmental dynamics of the definitive mouse placenta assessed by stereology [J].
Coan, PM ;
Ferguson-Smith, AC ;
Burton, GJ .
BIOLOGY OF REPRODUCTION, 2004, 70 (06) :1806-1813
[10]   The developmental origins of adult disease (Barker) hypothesis [J].
De Boo, HA ;
Harding, JE .
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 2006, 46 (01) :4-14