Moderate-volume samplers were used for collecting PM2.5 samples at six sites of Nanchang in Autumn of 2013. The pollution characteristics and the potential ecological risks of Ti, V, Co, Cr, Mn, Ni, Cu, Zn, Cd, Pb, As and Hg in PM2.5 were all analyzed. The results showed that the sequence of the mean concentration of heavy metals was: Hg<Co<Cd<V<As<Cu<Cr<Ti<Mn<Pb<Ni<Zn. More specifically, the mean concentrations of Ti, Ni, Ba and Pb were found slightly higher at FRI, while CES has the higher concentrations of Ti, V, Mn, Ni, Cu, Zn and Ba. Compared with enrichment factors and potential ecological risk indexes of heavy metal contamination, each level of contamination of heavy metals achieved the basic agreement. Ti, Mn and V were barely polluted; Cr, Co, Cu and As existed considerable pollution; the enrichment factors and potential ecological risk indexes of Hg, Zn, Pb, Ni and Cd were high, showing obvious anthropogenic pollution sources, while the potential ecological risk coefficient of Cd was extremely high, indicating serious pollution from human activities (such as industrial smoke, coal and fuel burning exhaust emissions).