Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons

被引：67

作者：

Moriguchi, T

Matsuura, H

Kodera, Y

Itakura, Y

Katsuki, H

Saito, H

Nishiyama, N

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,BUNKYO KU,TOKYO 113,JAPAN

[2] WAKUNAGA PHARMACEUT CO LTD,INST OTC RES,HIROSHIMA,JAPAN

来源：

NEUROCHEMICAL RESEARCH | 1997年 / 22卷 / 12期

关键词：

garlic; thioallyl group; rat hippocampus; neuronal survival; axonal branching;

D O I：

10.1023/A:1021946210399

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several organosulfur compounds found in garlic extract promoted the survival of rat hippocampal neurons in vitro. From the analysis of structure-activity relationship, thioallyl group in these compounds is essential for the manifestation of neurotrophic activity. S-Allyl-L-cysteine (SAG), one of the organosulfur compounds having thioallyl group in garlic extract, also promoted the axonal branching of cultured neurons. These results suggest that thioallyl compounds make a unique group of neurotrophic factors.

引用

页码：1449 / 1452

页数：4

共 16 条

[1] EFFECTS OF RECOMBINANT HUMAN BASIC FIBROBLAST GROWTH-FACTOR AND ITS MODIFIED PROTEIN CS23 ON SURVIVAL OF PRIMARY CULTURED NEURONS FROM VARIOUS REGIONS OF FETAL-RAT BRAIN [J].