Efficient synthesis routes for various phthalimido phosphor esters as antimicrobial agents in terms of structure-activity relationship

被引：14

作者：

Abdou, Wafaa Mahmoud ^{[1
]}

Khidre, Rizk E. ^{[1
]}

机构：

[1] Natl Res Ctr, Chem Ind Div, Giza 12622, Egypt

来源：

MONATSHEFTE FUR CHEMIE | 2010年 / 141卷 / 02期

关键词：

Phosphorylation; 1H-Isoindole-1,3(2H)-dione-2-derivatives; Structure-activity relationship; Amidophosphates; Antibiotics; ACID; DERIVATIVES; CYCLIZATION; AMINES;

D O I：

10.1007/s00706-009-0244-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of phthalimido phosphor derivatives-alpha-amino-phosphonates, amidophosphonates, phosphonic acid diamides, and oxadiazaphospholes-were prepared by applying different types of phosphorus(III) reagents to 2-methoxy-1H-isoindole-1,3(2H)-dione and 2-anilino-1H-isoindole-1,3(2H)-dione. On the basis of bioassay results, some of the new phosphoryl imides could be considered as lead molecules to be modified in order to improve their antibiotic activity.

引用

页码：219 / 228

页数：10

共 33 条

[1]

BARALDI PG, 1982, SYNTHESIS-STUTTGART, P653

[2] STUDIES ON PHOSPHONIUM YLIDES .18. THE REACTION OF WITTIG REAGENTS WITH PHTHALIMIDOBENZOIC ACID AZIDES [J].