Determination of the enantiomeric purity of the phytoalexins spirobrassinins by 1H NMR using chiral solvation

被引：27

作者：

Pedras, MSC ^{[1
]}

Hossain, M ^{[1
]}

Sarwar, MG ^{[1
]}

Montaut, S ^{[1
]}

机构：

[1] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 5C9, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 22期

基金：

加拿大自然科学与工程研究理事会;

关键词：

spirobrassinin; 1-methoxyspirobrassinin; enantiomeric purity; chiral solvation;

D O I：

10.1016/j.bmcl.2004.09.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simple and inexpensive method for enantiomeric discrimination of the phytoalexins spirobrassinin (1), 1-methoxyspirobrassinin (2) and synthetic analog 1-methylspirobrassinin (6) using the chiral solvating agent 2,2,2-trifluoro-1-(9-anthryl)ethanol in C6D6 is described. Using this method the enantiomeric composition of each sample can be determined accurately by H-1 NMR and the compounds can be recovered readily by chromatography. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5469 / 5471

页数：3

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