Determination of the enantiomeric purity of the phytoalexins spirobrassinins by 1H NMR using chiral solvation

被引：27
|
作者：
Pedras, MSC [1 ]
Hossain, M [1 ]
Sarwar, MG [1 ]
Montaut, S [1 ]
机构：
[1] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 5C9, Canada
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 22期
基金：
加拿大自然科学与工程研究理事会;
关键词：
spirobrassinin; 1-methoxyspirobrassinin; enantiomeric purity; chiral solvation;
D O I：
10.1016/j.bmcl.2004.09.014
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A simple and inexpensive method for enantiomeric discrimination of the phytoalexins spirobrassinin (1), 1-methoxyspirobrassinin (2) and synthetic analog 1-methylspirobrassinin (6) using the chiral solvating agent 2,2,2-trifluoro-1-(9-anthryl)ethanol in C6D6 is described. Using this method the enantiomeric composition of each sample can be determined accurately by H-1 NMR and the compounds can be recovered readily by chromatography. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5469 / 5471
页数：3
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