Preparation and Characterization of Oleanolic Acid-Based Low-Molecular-Weight Supramolecular Hydrogels Induced by Heating

被引：37

作者：

Fan, Jie-Ping ^{[1
,2
]}

Zhong, Hui ^{[2
]}

Zhang, Xue-Hong ^{[3
]}

Yuan, Tian-Tao ^{[2
]}

Chen, Hui-Ping ^{[1
,2
]}

Peng, Hai-Long ^{[1
,2
]}

机构：

[1] Nanchang Univ, Minist Educ, Key Lab Poyang Lake Ecol & Bioresource Utilizat, Nanchang 330031, Jiangxi, Peoples R China

[2] Nanchang Univ, Sch Resource Environm & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China

[3] Nanchang Univ, Sch Foreign Language, Nanchang 330031, Jiangxi, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2021年 / 13卷 / 24期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

oleanolic acid; choline; low-molecular-weight supramolecular hydrogels; natural product hydrogelator; heat induction; HIGHLY EFFICIENT; GEL FORMATION; URSOLIC ACID; FLUOROPHORES; ENTRAPMENT; SODIUM;

D O I：

10.1021/acsami.1c05800

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The natural-product-based low-molecular-weight supramolecular hydrogels (LMWSHs) induced by heating are rarely reported. In this work, a simple salt of oleanolic acid (OA) and choline ([choline][OA]) was used as the natural product hydrogelator (NPHG) to form LMWSHs. Unlike common sol-gel transitions, the OA-based LMWSH displayed a unique property with which the system could undergo a phase transition from the sol state to the gel state upon heating. Moreover, the phase separation was observed in sol and gel states when the temperature was elevated with nonreversible transparent-turbid transitions. LMWSHs showed good stability and injectability and the potential to be a drug delivery vehicle for sustained release of drugs. In this regard, this work provided a facile approach to designing an OA-based NPHG for preparing heat-induced LMWSHs.

引用

页码：29130 / 29136

页数：7

共 40 条

[1] Vesicular self-assembly of a natural ursane-type dihydroxy-triterpenoid corosolic acid [J].

Bag, Braja G. ;

Garai, Chhabi ;

Ghorai, Subrata .

RSC ADVANCES, 2019, 9 (27) :15190-15195

[2] First Self-Assembly of Dihydroxy Triterpenoid Maslinic Acid Yielding Vesicles [J].

Bag, Braja Gopal ;

Hasan, Sk Nurul ;

Ghorai, Subrata ;

Panja, Saikat Kumar .

ACS OMEGA, 2019, 4 (04) :7684-7690

[3] Nanoarchitectures by hierarchical self-assembly of ursolic acid: entrapment and release of fluorophores including anticancer drug doxorubicin [J].

Bag, Braja Gopal ;

Das, Subhajit ;

Hasan, Sk Nurul ;

Barai, Abir Chandan .

RSC ADVANCES, 2017, 7 (29) :18136-18143

[4] Self-assembly of sodium and potassium betulinates into hydro- and organo-gels: entrapment and removal studies of fluorophores and synthesis of gel-gold nanoparticle hybrid materials [J].

Bag, Braja Gopal ;

Dash, Shib Shankar .

RSC ADVANCES, 2016, 6 (21) :17290-17296

[5] Vesicular and Fibrillar Gels by Self-Assembly of Nanosized Oleanolic Acid [J].

Bag, Braja Gopal ;

Paul, Koushik .

ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 1 (02) :150-154

[6] Self-assembly of a renewable nano-sized triterpenoid 18β-glycyrrhetinic acid [J].

Bag, Braja Gopal ;

Majumdar, Rakhi .

RSC ADVANCES, 2012, 2 (23) :8623-8626

[7] First self-assembly study of betulinic acid, a renewable nano-sized, 6-6-6-6-5 pentacyclic monohydroxy triterpenic acid [J].

Bag, Braja Gopal ;

Dash, Shib Shankar .

NANOSCALE, 2011, 3 (11) :4564-4566

[8] Thermo-switchable surfactant gel [J].

Chu, Zonglin ;

Feng, Yujun .

CHEMICAL COMMUNICATIONS, 2011, 47 (25) :7191-7193

[9] Polymers Exhibiting Lower Critical Solution Temperatures as a Route to Thermoreversible Gelators for Healthcare [J].

Cook, Michael T. ;

Haddow, Peter ;

Kirton, Stewart B. ;

McAuley, William J. .

ADVANCED FUNCTIONAL MATERIALS, 2021, 31 (08)

[10] Semi-bald Micelles and Corresponding Percolated Micelle Networks of Thermogels [J].

Cui, Shuquan ;

Yu, Lin ;

Ding, Jiandong .

MACROMOLECULES, 2018, 51 (16) :6405-6420

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