Integrin Proteomes Reveal a New Guide for Cell Motility

被引：17

作者：

Danen, Erik H. J. ^{[1
]}

机构：

[1] Leiden Univ, Div Toxicol, Leiden Amsterdam Ctr Drug Res, Leiden, Netherlands

来源：

SCIENCE SIGNALING | 2009年 / 2卷 / 89期

关键词：

ADHESION; CROSSTALK; RAC; TRAFFICKING; ACTIVATION; RHO;

D O I：

10.1126/scisignal.289pe58

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Integrin transmembrane receptors orchestrate signaling cascades by recruiting cytoskeletal linker proteins and enzymes to sites of cell adhesion. A proteomics-based view of such integrin-associated signaling networks is now available. Besides the usual suspects, the interactomes contain several proteins that were not previously connected to integrins. One of these, regulator of chromosome condensation-2 (RCC2), represents an unexpected molecular connection between integrins and the cell-migration machinery.

引用

页数：2

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