THE ROLE OF REGULATORY T CELLS IN ALLERGIC CONTACT DERMATITIS

被引：0

作者：

Krecisz, Beata ^{[1
]}

Chomiczewska, Dorota ^{[1
]}

Kiec-Swierczynska, Marta ^{[1
]}

机构：

[1] Inst Med Pracy Prof J Nofera, Osrodek Alergii Zawodowej & Zdrowia Srodowiskoweg, PL-91348 Lodz, Poland

来源：

MEDYCYNA PRACY | 2009年 / 60卷 / 04期

关键词：

regulatory T cells; CD4+CD25+cells; allergic contact dermatitis; AIRWAY INFLAMMATION; CD4(+)CD25(+); TOLERANCE; HEALTHY; DISEASE; SUPPRESSION; EXPRESSION; INDUCTION; MECHANISM; NICKEL;

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Regulatory T cells (Treg) play a crucial role in the regulatory mechanisms of immune system. They are responsible for the induction and maintenance of immune tolerance. They are also involved in the pathogenesis of autoimmune and allergic diseases and implicated in transplant rejection and immunopathology of cancers. Treg cells constitute the population of lymphocytes heterogeneous in their phenotype. CD4+CD25+Foxp3+ cells are most important among Treg subsets. Modification of Treg actvity may be useful in the therapy of different diseases, including allergic disorders. Med Pr 2009;60(4):315-319

引用

页码：315 / 319

页数：5

共 31 条

[1] Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells [J].

Akdis, M ;

Verhagen, J ;

Taylor, A ;

Karamloo, F ;

Karagiannidis, C ;

Crameri, R ;

Thunberg, S ;

Deniz, G ;

Valenta, R ;

Fiebig, H ;

Kegel, C ;

Disch, R ;

Schmidt-Weber, CB ;

Blaser, K ;

Akdis, CA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (11) :1567-1575

[2] Mechanisms of T regulatory cell function [J].

Askenasy, Nadir ;

Kaminitz, Ayelet ;

Yarkoni, Shai .

AUTOIMMUNITY REVIEWS, 2008, 7 (05) :370-375

[3] Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals [J].

Cavani, A ;

Nasorri, F ;

Ottaviani, C ;

Sebastiani, S ;

De Pità, O ;

Girolomoni, G .

JOURNAL OF IMMUNOLOGY, 2003, 171 (11) :5760-5768

[4] Specialization in tolerance:: Innate CD4+CD25+ versus acquired TR1 and TH3 regulatory T cells [J].

Cottrez, F ;

Groux, H .

TRANSPLANTATION, 2004, 77 (01) :S12-S15

[5] The IL-6R α chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo [J].

Doganci, A ;

Eigenbrod, T ;

Krug, N ;

De Sanctis, GT ;

Hausding, M ;

Erpenbeck, VJ ;

Haddad, EB ;

Schmitt, E ;

Bopp, T ;

Kallen, KJ ;

Herz, U ;

Schmitt, S ;

Luft, C ;

Hecht, O ;

Hohlfeld, JM ;

Ito, H ;

Nishimoto, N ;

Yoshizaki, K ;

Kishimoto, T ;

Rose-John, S ;

Renz, H ;

Neurath, MF ;

Galle, PR ;

Finotto, S .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (02) :313-325

[6]

Elkord Eyad, 2006, Inflammation & Allergy Drug Targets, V5, P211, DOI 10.2174/187152806779010945

[7] CD4+ Tregs and immune control [J].

Fehérvari, Z ;

Sakaguchi, S .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (09) :1209-1217

[8] Regulatory T cells in allergic disease [J].

Foley, Susan C. ;

Prefontaine, David ;

D'Antoni, Michelle ;

Hamid, Qutayba .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (02) :482-486

[9]

GERSHON RK, 1971, IMMUNOLOGY, V21, P903

[10]

Gober Michael D., 2008, V10, P1, DOI 10.1159/000131410

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