Redox-active metal(II) complexes of sterically hindered phenolic ligands: Antibacterial activity and reduction of cytochrome c

被引：6
作者：
Loginova, N. V. [1 ]
Faletrov, Y. V. [2 ]
Koval'chuk, T. V. [1 ,2 ]
Osipovich, N. P. [2 ]
Polozov, G. I. [1 ]
Chernyavskaya, A. A. [4 ]
Zheldakova, R. A. [1 ]
Azarko, I. I. [3 ]
Gres, A. T. [1 ]
Shadyro, O. I. [1 ]
Shkumatov, V. M. [1 ]
机构：
[1] Belarusian State Univ, Fac Chem, Minsk 220030, BELARUS
[2] Belarusian State Univ, Res Inst Physicochem Problems, Minsk 220030, BELARUS
[3] Belarusian State Univ, Fac Phys, Minsk 220030, BELARUS
[4] RUE Ctr Examinat & Tests Hlth Service, Minsk 220037, BELARUS
来源：
POLYHEDRON | 2010年 / 29卷 / 06期
关键词：
Metal(II) complexes; Sterically hindered phenolic ligands; Cytochrome c; Cytochrome P450-reductase; Antibacterial activity; COPPER(II) COMPLEXES; ANTIFUNGAL ACTIVITY; P450; REDUCTASE; COBALT(III) COMPLEXES; FERRICYTOCHROME-C; CRYSTAL-STRUCTURE; SUPEROXIDE; OXIDATION; KINETICS; MANGANESE(II);
D O I：
10.1016/j.poly.2010.02.007
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis and physico-chemical characterization of Fe(II) and Mn(II) complexes of 4,6-di-tert-buty-3[(2-hydroxyethyl)sulphanyl]-1,2-dihydroxybenzene (HLI) and 2-amino-4,6-di-tert-butylphenol (HLII) were carried out. Antibacterial activity of the Co(II), Fe(II) and Mn(II) complexes was evaluated in comparison with Cu(II) complexes and three common antibiotics; it was found to follow the order: (1) Cu(L-I)(2) > Co(L-I)(2) > Fe(L-I)(2) >= Mn(L-I)(2) > HLI; (2) Cu(L-II)(2) > Co(L-II)(2) > HLII > Fe(L-II)(2) >= Mn(L-II)(2); and their reducing ability (determined electrochemically) followed the same order. Spectrophotometric investigation was carried out in order to estimate the rate of the reduction of bovine heart cytochrome c with the ligands and their metal(II) complexes. NADPH:cytochrome P450-reductase was found to increase the rate of cytochrome c reduction with HLI and HLII ligands, while adrenodoxin in couple with NAD(P)H: adrenodoxin reductase had no substantial effect thereon. It was shown that the reduction of cytochrome c with these compounds cannot be related solely to the facility of their oxidation or ionization. (C) 2010 Elsevier Ltd. All rights reserved.
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页码：1646 / 1652
页数：7
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