Synthesis and Characterization of Gadolinium Diethylenetriamine Pentaacetate-Folate

被引：6

作者：

Fauzia, R. P. ^{[1
]}

Mutalib, A. ^{[2
]}

Soedjanaatmadja, R. U. M. S. ^{[1
]}

Bahti, H. H. ^{[1
]}

Anggraeni, A. ^{[1
]}

Gunawan, A. H. ^{[1
]}

Pujiastuti, H. ^{[3
]}

Hidayati, Y. ^{[3
]}

机构：

[1] Padjadjaran State Univ, Fac Math & Nat Sci, Dept Chem, Jl Raya Bandung Sumedang Km 21 Jatinangor, Sumedang 45363, Indonesia

[2] Natl Nucl Energy Agcy, Ctr Radioisotopes & Radiopharmacet Technol, Kawasan Puspiptek Serpon 15314, Tanggerang Sela, Indonesia

[3] PT Kimia Farma Tbk, Bandung 40171, Indonesia

来源：

3RD INTERNATIONAL SEMINAR ON CHEMISTRY 2014 | 2015年 / 17卷

关键词：

Folic acid; DTPA-Folate; Gd-DTPA-Folate; cancer; Magnetic Resonance Imaging;

D O I：

10.1016/j.proche.2015.12.128

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In our preliminary radiopharmaceutical study, Gd-153-DTPA-Folate has been successfully prepared, and tested for its bio-distribution. This continuing study is aimed at synthesizing and characterizing Gd-DTPA-Folate. The synthesis was started with the preparation of a derivative of folic acid, EDA-Folate, which was subsequently reacted with DTPA-Dianhydride to form DTPA-Folate. Finally, DTPA-Folate was reacted with Gd3+ to result in Gd-DTPA-Folate, on a 0.1-10 gram scale, with a yield of 97.2%. Experimental data collected from characterization of purified synthetic products using ultraviolet, infrared, and mass spectroscopy, indicated the formation of Gd-O and Gd-N bonds leading to the formation of Gd-DTPA-Folate molecule.

引用

页码：139 / 146

页数：8

共 50 条

[21] Synthesis and Characterization of Water Soluble Diethylenetriamine-β-Cyclodextrin/Ethinylestradiol Inclusion Complex
Gong, Fengrong
Lv, Rongyao
Ma, Jiayue
Wang, Xuehan
Qu, Yanmei
Zhang, Cong
Xu, Juan
Wang, Ting
CHEMISTRYSELECT, 2022, 7 (37):
[22] Synthesis and characterization of imidazolinium surfactants derived from tallow fatty acids and diethylenetriamine
Bajpai, Divya
Tyagi, Vinod K.
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 2008, 110 (10) : 935 - 940
[23] Synthesis and characterization of gadolinium-silica precipitation tubes
Sabal, Christopher
Weller, Daniel
Pagano, Jason
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
[24] Synthesis and characterization of novel biodegradable folate conjugated polyurethanes
Yu, Lunquan
Zhou, Lijuan
Ding, Mingming
Li, Jiehua
Tan, Hong
Fu, Qiang
He, Xueling
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2011, 358 (02) : 376 - 383
[25] Synthesis, characterization, thermal constant and relaxation of gadolinium(III), iron(III) and manganese(II) chelates of diethylenetriamine-bis-inositol-N,N′N"-triacetic acid
Tang, HA
Sheng, Y
Yang, RD
INORGANIC CHEMISTRY COMMUNICATIONS, 2003, 6 (09) : 1213 - 1216
[26] Synthesis, characterization, and anticancer activity of folate γ-ferrocenyl conjugatest
Bertuzzi, Diego L.
Perli, Gabriel
Braga, Carolyne B.
Ornelas, Catia
NEW JOURNAL OF CHEMISTRY, 2020, 44 (12) : 4694 - 4703
[27] Synthesis, Characterization and Crystal Structure of Quaternary Complex of Gadolinium (Ⅲ)
朱龙观
蔡国强
王国平
北川进
正冈重行
Journal of Rare Earths, 2003, (01) : 9 - 12
[28] Synthesis, characterization and reactivity of yttrium and gadolinium silyl complexes
Sgro, Michael J.
Piers, Warren E.
INORGANICA CHIMICA ACTA, 2014, 422 : 243 - 250
[29] Synthesis and characterization of gadolinium colloids in 2-methoxyethanol
Cardenas Trivino, Galo
Godoy Guzman, Olivia
Guillermo Contreras, J.
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, 2006, 51 (03): : 989 - 992
[30] REDUCTION OF HYDROGEN-PEROXIDE BY THE FERROUS IRON CHELATE OF DIETHYLENETRIAMINE-N,N,N',N'',N''-PENTAACETATE
RAHHAL, S
RICHTER, HW
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (10) : 3126 - 3133

← 1 2 3 4 5 →