Chemopreventive potential of alpha lipoic acid in the treatment of colon and cervix cancer cell lines

被引：16

作者：

Damnjanovic, I ^{[1
]}

Kocic, G. ^{[2
]}

Najman, S. ^{[3
]}

Stojanovic, S. ^{[3
]}

Stojanovic, D. ^{[4
]}

Veljkovic, A. ^{[2
]}

Conic, I ^{[5
]}

Langerholc, T. ^{[6
]}

Pesic, S. ^{[7
]}

机构：

[1] Univ Nis, Fac Med, Dept Pharm, Nish, Serbia

[2] Univ Nis, Fac Med, Inst Biochem, Nish, Serbia

[3] Univ Nis, Fac Med, Inst Biol & Human Genet, Nish, Serbia

[4] Univ Nis, Fac Med, Inst Pathophysiol, Nish, Serbia

[5] Clin Ctr Nis, Clin Oncol, Nish, Serbia

[6] Univ Maribor, Fac Med, Maribor, Slovenia

[7] Univ Nis, Fac Med, Dept Pharmacol, Nish, Serbia

来源：

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2014年 / 115卷 / 10期

关键词：

alpha lipoic acid; chemoprevention; HeLa cells; Caco-2; cells; nuclear factor kappa B; NF-KAPPA-B; IN-VITRO; ACTIVATION; PROLIFERATION; ANGIOGENESIS; PROGRESSION; EXPRESSION; APOPTOSIS; P53; KB;

D O I：

10.4149/BLL_2014_118

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: The nuclear factor kappa B regulates the expression of genes involved in many processes that play a key role in the development and progression of cancer. The aim of this study was to examine the influence of the alpha lipoic acid in the chemoprevention of colon and cervix carcinoma in vitro. Background: In recent years, special attention has been paid to the potential chemopreventive properties of antioxidants. There are no published data on the impact of alpha lipoc acid of chemoprevention of cervix and colon cancer. Methods: We examined the effect of alpha lipoic acid alone or in combination with cisplatin and 5-fluorouracil on proliferation of the two cell lines, HeLa (human cervical carcinoma cells) and Caco-2 (human colon cancer cells) by MTT test. The measurement of the level of transcription factor NF-kappa B was also performed in the cells of both cell lines. Results: At least one of the mechanisms of the antiproliferative and/or cytotoxic effect of alpha lipoic acid on Caco-2 and HeLa cells at high concentrations, the transcription factor NF-kappa B, may be involved, as well as the products of transcription of genes that are under its control. Conclusion: The alpha lipoic acid has proven to be a promising candidate in the combat arena against cancer (Tab. 4, Ref. 31). Text in PDF www.elis.sk.

引用

页码：611 / 616

页数：6

共 30 条

[1] Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells [J].