Highly selective aziridination of imines using trimethylsilyldiazomethane and applications of C-silylaziridines in synthesis

被引：62

作者：

Aggarwal, VK ^{[1
]}

Ferrara, M ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 25期

关键词：

D O I：

10.1021/ol006772h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Trimethylsilyldiazomethane has been found to add directly to N-sulfonyl (Ts and SES) imines to afford aziridines in good yields and high cis stereoselectivities. The silyl group can be substituted by treatment with a fluoride source and electrophiles again with high selectivity. Complete regioselectivity is observed in ring opening of these aziridines with nucleophiles.

引用

页码：4107 / 4110

页数：4

共 41 条

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