Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction

被引：80
作者：
Oishi, Yuichi
Sakamoto, Tatsuaki
Udagawa, Haruhide
Taniguchi, Hironobu
Kobayashi-Hattori, Kazuo
Ozawa, Yoshio
Takita, Toshichika
机构：
[1] Tokyo Univ Agr, Fac Appl Biosci, Dept Nutrit Sci, Setagaya Ku, Tokyo 1568502, Japan
[2] Toita Womans Coll, Dept Nutrit Sci & Culinary Arts, Minato Ku, Tokyo 1050014, Japan
[3] Takasaki Univ Hlth & Welf, Dept Hlth & Nutr, Gunma 3700033, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2007年 / 71卷 / 03期
关键词：
Momordica charantia; saponin fraction; blood glucose; serum neutral fat; rats;
D O I：
10.1271/bbb.60570
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Focusing on a functional component of Momordica charantia, saponin, we investigated its effects on serum glucose and neutral fat levels. Saponin was extracted as a butanol-soluble fraction (saponin fraction) from hot blast-dried Momordica charantia powder. The disaccharidase-inhibitory activity and the pancreatic lipase-inhibitory activity of the saponin fraction were measured, and in vivo sugar- and lipid-loading tests were performed. The saponin fraction inhibited disaccharidase activity and elevation of the blood glucose level after sucrose loading. The fraction also markedly inhibited pancreatic lipase activity and elevation of the serum neutral fat level after corn oil loading. Based on these findings, the main active component related to the anti-diabetic effect of Momordica charantia is present in the butanol fraction, and it may be saponin. The blood glucose and serum neutral fat-lowering effects of Momordica charantia were closely associated with its inhibitory activity against disaccharidase and pancreatic lipase.
引用
收藏
页码：735 / 740
页数：6
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