AIE-based cancer theranostics

被引：165

作者：

Gao, Meng ^{[1
]}

Tang, Ben Zhong ^{[2
,3
,4
]}

机构：

[1] South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Key Lab Biomed Mat & Engn,Minist Educ, Key Lab Biomed Engn Guangdong Prov,Innovat Ctr Ti, Guangzhou 510006, Guangdong, Peoples R China

[2] South China Univ Technol, Ctr Aggregat Induced Emiss, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Guangdong, Peoples R China

[3] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Inst Adv Study, Dept Chem,Hong Kong Branch,Kowloon, Clear Water Bay, Hong Kong, Peoples R China

[4] Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Clear Water Bay, Hong Kong, Peoples R China

来源：

COORDINATION CHEMISTRY REVIEWS | 2020年 / 402卷

基金：

美国国家科学基金会;

关键词：

Aggregation-induced emission; Cancer theranostics; Fluorescence; Chemotherapy; Photodynamic therapy; Photothermal therapy; Gene therapy; Synergistic therapy; AGGREGATION-INDUCED-EMISSION; PHOTODYNAMIC ABLATION; DRUG-DELIVERY; IN-VIVO; POLYMER NANOPARTICLES; ORGANIC NANOPARTICLES; SILVER NANOCLUSTERS; FLUORESCENT-PROBES; HIGHLY EFFICIENT; QUANTUM YIELD;

D O I：

10.1016/j.ccr.2019.213076

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Theranostics with simultaneous diagnosis and therapy functions are potential to greatly improve the therapeutic efficacy and reduce side effects. Fluorescence imaging has significant advantages in terms of high sensitivity, easy operation, and good biocompatibility. However, traditional fluorophores usually suffer from serious self-quenching after local accumulation at a high concentration. In contrary, the aggregation-induced emission fluorogens (AIEgens) are ideal for construction of cancer theranostics with advantages of high emission efficiency in the aggregate state. Therefore, the combination of AlEgens and different therapy modules provides a great opportunity for image-guided precise cancer treatment, which can efficiently ablate cancer cells both in vitro and in vivo. In this review, we will discuss the most recent progress of AIE-based cancer theranostics with representative examples. (C) 2019 Elsevier B.V. All rights reserved.

引用

页数：41

共 175 条

[1]

[Anonymous], ANGEW CHEM INT ED

[2]

[Anonymous], ANGEW CHEM INT ED

[3]

[Anonymous], CHEM SCI

[4] Next revolution in molecular theranostics: personalized medicine for urologic cancers [J].

Aoun, Fouad ;

Kourie, Hampig Raphael ;

Artigas, Carlos ;

Roumeguere, Thierry .

FUTURE ONCOLOGY, 2015, 11 (15) :2205-2219

[5] Gold nanoparticles in combinatorial cancer therapy strategies [J].

Beik, Jaber ;

Khateri, Maziar ;

Khosravi, Zohreh ;

Kamrava, S. Kamran ;

Kooranifar, Siavash ;

Ghaznavi, Habib ;

Shakeri-Zadeh, Ali .

COORDINATION CHEMISTRY REVIEWS, 2019, 387 :299-324

[6] Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy [J].

Cai, Xiaolei ;

Bandla, Aishwarya ;

Chuan, Chan Kim ;

Magarajah, Gayathiri ;

Liao, Lun-De ;

Teh, Daniel Boon Loong ;

Kennedy, Brian K. ;

Thakor, Nitish V. ;

Liu, Bin .

MATERIALS HORIZONS, 2019, 6 (02) :311-317

[7] Multifunctional Liposome: A Bright AIEgen-Lipid Conjugate with Strong Photosensitization [J].

Cai, Xiaolei ;

Mao, Duo ;

Wang, Can ;

Kong, Deling ;

Cheng, Xiamin ;

Liu, Bin .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (50) :16396-16400

[8] Organic Mitoprobes based on Fluorogens with Aggregation-Induced Emission [J].

Cai, Xiaolei ;

Hu, Fang ;

Feng, Guangxue ;

Kwok, Ryan Tsz Kin ;

Liu, Bin ;

Tang, Ben Zhong .

ISRAEL JOURNAL OF CHEMISTRY, 2018, 58 (08) :860-873

[9] Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization [J].

Celli, Jonathan P. ;

Spring, Bryan Q. ;

Rizvi, Imran ;

Evans, Conor L. ;

Samkoe, Kimberley S. ;

Verma, Sarika ;

Pogue, Brian W. ;

Hasan, Tayyaba .

CHEMICAL REVIEWS, 2010, 110 (05) :2795-2838

[10]

CHATTERJEE SK, 1979, CANCER RES, V39, P1943

← 1 2 3 4 5 6 7 8 9 10 →