Kidney Transplantation, Cardiovascular Risk, and Long-Term Dialysis in Japan

被引：1

作者：

Tada, M. ^{[1
]}

Hasegawa, M. ^{[1
]}

Sasaki, H. ^{[2
]}

Kusaka, M. ^{[2
]}

Shiroki, R. ^{[2
]}

Hoshinaga, K. ^{[2
]}

Ito, T. ^{[3
]}

Kenmochi, T. ^{[3
]}

Nakai, S. ^{[4
]}

Takahashi, K. ^{[1
]}

Hayashi, H. ^{[1
]}

Koide, S. ^{[1
]}

Yuzawa, Y. ^{[1
]}

机构：

[1] Fujita Hlth Univ, Sch Med, Dept Nephrol, 1-98 Dengakugakubo Kutukaek Cho, Toyoake, Aichi 4701192, Japan

[2] Fujita Hlth Univ, Sch Med, Dept Urol, Toyoake, Aichi 4701192, Japan

[3] Fujita Hlth Univ, Sch Med, Dept Organ Transplantat, Toyoake, Aichi 4701192, Japan

[4] Fujita Hlth Univ, Sch Hlth Sci, Toyoake, Aichi 4701192, Japan

来源：

TRANSPLANTATION PROCEEDINGS | 2016年 / 48卷 / 01期

基金：

日本学术振兴会;

关键词：

DISEASE; PATIENT;

D O I：

10.1016/j.transproceed.2015.12.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. The waiting time for deceased-donor kidney-only transplantations in Japan is long. Herein, we assessed the effect of length of dialysis on the outcomes of these patients. Methods. We divided patients into 2 groups based on length of dialysis (Group A, <15 years, and Group B, >= 15 years), and compared the background and outcomes after kidney transplantation. Results. Group A included 210 patients and Group B included 35 patients. In Group B, 20% of transplants were from living donors. Patient age (P = .017) and the hepatitis C infection rate (P = .018) were significantly higher in Group B, whereas hypertension (P = .011), diabetes (P = .041), and ABO-incompatibility rates (P = .015) were significantly higher in Group A. The 5- and 10-year survival rates were 97.0% and 95.4%, respectively, in Group A and 97.1% and 97.1%, respectively, in Group B. The 5- and 10-year graft survival rates were 95.4% and 84.8%, respectively, in Group A and 97.1% and 73.1%, respectively, in Group B. There were no significant differences between the groups in patient survival (P = .74) and graft survival (P = .72). The 5- and 10-year cardiovascular event-free survival rates were 95.9% and 92.4%, respectively, in Group A and 88.6% and 76.8%, respectively, in Group B. Cardiovascular event-free survival was significantly higher in Group A (P = .038). Cox stepwise multivariate analysis indicated that length of dialysis was a significant predictor of cardiovascular events (hazard risk, 1.007; range, 1.001-1.012; P = .012). Conclusion. The prognosis after kidney transplantation is promising even after a long length of dialysis, although evaluation of the cardiovascular risk is needed in these cases.

引用

页码：26 / 30

页数：5

共 10 条

[1] Patient survival after renal transplantation: I. The impact of dialysis pre-transplant [J].