Natural product derived insecticides: discovery and development of spinetoram

被引：54

作者：

Galm, Ute ^{[1
]}

Sparks, Thomas C. ^{[1
]}

机构：

[1] Dow AgroSci LLC, 9330 Zionsville Rd, Indianapolis, IN 46268 USA

来源：

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | 2016年 / 43卷 / 2-3期

关键词：

Saccharopolyspora spinosa; Spinosyn; Spinetoram; Natural products; Insecticide; SACCHAROPOLYSPORA-SPINOSA; NEURAL-NETWORKS; BIOSYNTHESIS; IDENTIFICATION; RHAMNOSE; GENES;

D O I：

10.1007/s10295-015-1710-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This review highlights the importance of natural product research and industrial microbiology for product development in the agricultural industry, based on examples from Dow AgroSciences. It provides an overview of the discovery and development of spinetoram, a semi synthetic insecticide derived by a combination of a genetic block in a specific O-methylation of the rhamnose moiety of spinosad coupled with neural network-based QSAR and synthetic chemistry. It also emphasizes the key role that new technologies and multidisciplinary approaches play in the development of current spinetoram production strains.

引用

页码：185 / 193

页数：9

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