The role of m6A methylation in osteosarcoma biological processes and its potential clinical value

被引：16

作者：

Wu, Yanjiao ^{[1
,2
]}

Wang, Zhiyun ^{[1
]}

Shen, Jianlin ^{[6
]}

Yan, Wei ^{[7
]}

Xiang, Shurong ^{[2
]}

Liu, Huan ^{[5
]}

Huang, Wenhua ^{[1
,2
,3
,4
]}

机构：

[1] Southern Med Univ, Shunde Hosp, Peoples Hosp Shunde 1, Foshan, Peoples R China

[2] Southern Med Univ, Sch Basic Med Sci, Guangdong Prov Key Lab Med Biomech, Guangzhou, Peoples R China

[3] Southern Med Univ, Guangdong Engn Res Ctr Translat Med Printing Appl, Guangzhou, Peoples R China

[4] Southern Med Univ, Guangdong Innovat Platform Translat Printing Appl, Guangzhou, Peoples R China

[5] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Dept Orthopaed, Luzhou, Peoples R China

[6] Southern Med Univ, Precis Med Inst, Affiliated Hosp 3, Guangzhou, Peoples R China

[7] Hebei Med Univ, Dept Anat, Shijiazhuang, Hebei, Peoples R China

来源：

HUMAN GENOMICS | 2022年 / 16卷 / 01期

基金：

中国国家自然科学基金;

关键词：

m6A modification; Osteosarcoma; Epigenetics; Writers; Erasers; Readers; MESSENGER-RNA; PARTIAL-PURIFICATION; M(6)A METHYLATION; NUCLEAR-RNA; METHYLTRANSFERASE; PROGRESSION; N-6-METHYLADENOSINE; N6-METHYLADENOSINE; PROLIFERATION; TRANSLATION;

D O I：

10.1186/s40246-022-00384-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and young adults and has a poor prognosis. Recent developments in the field of high-throughput sequencing technology, particularly in methylated RNA immunoprecipitation sequencing (MeRIP-seq), have led to renewed interest in RNA methylation. Among the various RNA modifications, N6-methyladenosine (m6A) modifications are the most common. Emerging evidence suggests that m6A methylation can affect the complexity of cancer progression by regulating biological functions related to cancer. In this review, we will shed light on recent findings regarding the biological function of m6A methylation in OS and discuss future research directions and potential clinical applications of RNA methyltransferases in OS.

引用

页数：9

共 77 条

[1]

BOKAR JA, 1994, J BIOL CHEM, V269, P17697

[2] Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m6 a methyltransferase [J].

Bujnicki, JM ;

Feder, M ;

Radlinska, M ;

Blumenthal, RM .

JOURNAL OF MOLECULAR EVOLUTION, 2002, 55 (04) :431-444

[3] YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis [J].

Chang, Guoqiang ;

Shi, Lei ;

Ye, Youqiong ;

Shi, Hailing ;

Zeng, Lixian ;

Tiwary, Shweta ;

Huse, Jason T. ;

Huo, Lei ;

Ma, Li ;

Ma, Yongjie ;

Zhang, Sicong ;

Zhu, Jianwei ;

Xie, Victoria ;

Li, Peng ;

Han, Leng ;

He, Chuan ;

Huang, Suyun .

CANCER CELL, 2020, 38 (06) :857-+

[4] Recent Advances in Hyperthermia Therapy-Based Synergistic Immunotherapy [J].

Chang, Mengyu ;

Hou, Zhiyao ;

Wang, Man ;

Li, Chunxia ;

Lin, Jun .

ADVANCED MATERIALS, 2021, 33 (04)

[5] RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2 [J].

Chen, Mengnuo ;

Wei, Lai ;

Law, Cheuk-Ting ;

Tsang, Felice Ho-Ching ;

Shen, Jialing ;

Cheng, Carol Lai-Hung ;

Tsang, Long-Hin ;

Ho, Daniel Wai-Hung ;

Chiu, David Kung-Chun ;

Lee, Joyce Man-Fong ;

Wong, Carmen Chak-Lui ;

Ng, Irene Oi-Lin ;

Wong, Chun-Ming .

HEPATOLOGY, 2018, 67 (06) :2254-2270

[6] WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner [J].

Chen, Shijie ;

Li, Yuezhan ;

Zhi, Shuang ;

Ding, Zhiyu ;

Wang, Weiguo ;

Peng, Yi ;

Huang, Yan ;

Zheng, Ruping ;

Yu, Haiyang ;

Wang, Jianlong ;

Hu, Minghua ;

Miao, Jinglei ;

Li, Jinsong .

CELL DEATH & DISEASE, 2020, 11 (08)

[7] ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma [J].

Chen, Shuo ;

Zhou, Liwu ;

Wang, Yang .

CANCER CELL INTERNATIONAL, 2020, 20 (01)

[8] RNA methylation and diseases: experimental results, databases, Web servers and computational models [J].

Chen, Xing ;

Sun, Ya-Zhou ;

Liu, Hui ;

Zhang, Lin ;

Li, Jian-Qiang ;

Meng, Jia .

BRIEFINGS IN BIOINFORMATICS, 2019, 20 (03) :896-917

[9] Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer [J].

Chen, Yi ;

Lin, Yu ;

Shu, Yongqian ;

He, Jing ;

Gao, Wen .

MOLECULAR CANCER, 2020, 19 (01)

[10] Epigenetic modification of nucleic acids: from basic studies to medical applications [J].

Chen, Yuqi ;

Hong, Tingting ;

Wang, Shaoru ;

Mo, Jing ;

Tian, Tian ;

Zhou, Xiang .

CHEMICAL SOCIETY REVIEWS, 2017, 46 (10) :2844-2872

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