Guidelines for Infection Prophylaxis, Monitoring and Therapy in Cord Blood Transplantation

被引:21
作者
Olson, Amanda L. [1 ]
Politikos, Ioannis [2 ]
Brunstein, Claudio [1 ]
Milano, Fillipo [3 ]
Barker, Juliet [2 ]
Hill, Joshua A. [3 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[2] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
[3] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA
来源
TRANSPLANTATION AND CELLULAR THERAPY | 2021年 / 27卷 / 05期
关键词
infection prophylaxis; cord; blood transplantation; cbt; STEM-CELL TRANSPLANTATION; EPSTEIN-BARR-VIRUS; IMMUNE RECONSTITUTION; T-CELLS; RECIPIENTS; CYTOMEGALOVIRUS; ENCEPHALITIS; ADULT; PREVENTION; MORTALITY;
D O I
10.1016/j.jtct.2021.01.024
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
As an alternative stem cell source, cord blood (CB) has many advantages. However, delayed engraftment, lack of transferred immunity, and a significant incidence of acute graft-versus-host disease renders CB transplant (CBT) recipients at high risk of infectious complications. This guidance written by CBT and infectious disease experts outlines evidence-based recommendations for the prevention and treatment of opportunistic infections in adult patients undergoing CBT. Topics addressed include bacterial, fungal, viral, pneumocystis jirovcii and toxoplasmosis prophylaxis, suggested PCR monitoring for viruses, therapy for the most commonly encountered infections after CBT. We review key concepts including the recent important role of letermovir in the prevention of CMV reactivation. In instances where there is a paucity of data, practice recommendations are provided, including the duration of antimicrobial prophylaxis. (C) 2021 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:359 / 362
页数:4
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