The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes

被引：48

作者：

Olmos, Yolanda ^{[1
]}

机构：

[1] Univ Complutense Madrid, Sch Biol, Dept Cell Biol, Madrid 28040, Spain

来源：

MEMBRANES | 2022年 / 12卷 / 06期

关键词：

ESCRT; membrane scission; reverse topology; nuclear envelope; lysosome; membrane sealing; membrane repair; STRUCTURAL BASIS; CELL-DEATH; AUTOPHAGOSOME CLOSURE; DAMAGED LYSOSOMES; SORTING COMPLEX; VPS4; MECHANISMS; CLEARANCE; FISSION; CONSTRICTION;

D O I：

10.3390/membranes12060633

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III, together with the AAA ATPase VPS4, harbors the main remodeling and scission function of the ESCRT machinery, whereas early-acting ESCRTs mainly contribute to protein sorting and ESCRT-III recruitment through association with upstream targeting factors. Here, we review recent advances in our understanding of the molecular mechanisms that underlie membrane constriction and scission by ESCRT-III and describe the involvement of this machinery in the sealing and repairing of damaged cellular membranes, a key function to preserve cellular viability and organellar function.

引用

页数：16

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