Contemporary models for peripheral tolerance and the classical 'historical postulate'

被引：15

作者：

Bretscher, P ^{[1
]}

机构：

[1] Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK S7N 5E5, Canada

来源：

SEMINARS IN IMMUNOLOGY | 2000年 / 12卷 / 03期

基金：

英国医学研究理事会;

关键词：

peripheral tolerance; historical postulate; Th activation; inactivation; two step; two signal model;

D O I：

10.1006/smim.2000.0235

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The formulators of Clonal Selection Theory proposed that what distinguishes self from foreign antigens is their early appearance in development, and their continuous Presence thereafter This early presence of a self antigen in an animals life history was envisaged to ensure that lymphocytes specific for the self antigen were silenced rather than activated. I call this idea 'the historical postulate'. Contemporary models for the activation/inactivation of helper T cells implicitly violate this postulate. I argue against such a violation and for a model of T helper cell activation/inactivation that reconciles contemporary observations with the postulate.

引用

页码：221 / 229

页数：9

共 30 条

[1] NONTOLERANCE AND AUTOANTIBODIES TO A TRANSGENIC SELF ANTIGEN EXPRESSED IN PANCREATIC BETA-CELLS [J].

ADAMS, TE ;

ALPERT, S ;

HANAHAN, D .

NATURE, 1987, 325 (6101) :223-228

[2] Neutralizing antiviral B cell responses [J].

Bachmann, MF ;

Zinkernagel, RM .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :235-270

[3] REJECTION OF SKIN ALLOGRAFTS BY RADIATION CHIMAERAS - SELECTIVE GENE ACTION IN SPECIFICATION OF CELL SURFACE STRUCTURE [J].

BOYSE, EA ;

LANCE, EM ;

CARSWELL, EA ;

COOPER, S ;

OLD, LJ .

NATURE, 1970, 227 (5261) :901-&

[4]

BRETSCHER P, 1972, TRANSPLANT REV-DENMA, V11, P217

[5] A THEORY OF SELF-NONSELF DISCRIMINATION [J].

BRETSCHER, P ;

COHN, M .

SCIENCE, 1970, 169 (3950) :1042-+

[6] A two-step, two-signal model for the primary activation of precursor helper T cells [J].

Bretscher, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (01) :185-190

[7]

BURNET FM, 1959, CLONAL SELECTIUON TH

[8] EVIDENCE THAT THE T-CELL REPERTOIRE OF NORMAL RATS CONTAINS CELLS WITH THE POTENTIAL TO CAUSE DIABETES - CHARACTERIZATION OF THE CD4+ T-CELL SUBSET THAT INHIBITS THIS AUTOIMMUNE POTENTIAL [J].

FOWELL, D ;

MASON, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (03) :627-636

[9] SUPPRESSION OF ADOPTIVE ANTIBODY-RESPONSES BY ADDITION OF SPLEEN-CELLS FROM AGAMMAGLOBULINEMIC CHICKENS IMMUNIZED WITH HISTOCOMPATIBLE BURSA CELLS [J].

GREBENAU, MD ;

LERMAN, SP ;

PALLADINO, MA ;

THORBECKE, GJ .

NATURE, 1976, 260 (5546) :46-48

[10] Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity [J].

Hanahan, D .

CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (06) :656-662

← 1 2 3 →