Of mice and men: hybridoma and recombinant antibodies

被引：88
作者：
Little, M
Kipriyanov, SM
Le Gall, F
Moldenhauer, G
机构：
[1] Affirmed Therapeut AG, D-68526 Ladenburg, Germany
[2] German Canc Res Ctr, D-69120 Heidelberg, Germany
来源：
IMMUNOLOGY TODAY | 2000年 / 21卷 / 08期
关键词：
D O I：
10.1016/S0167-5699(00)01668-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Thousands of mouse monoclonal antibodies have been produced from hybridomas over the past 25 years. The same technique can now be used to clone human antibodies from transgenic mice. Full-length antibodies and recombinant fragments engineered for various diagnostic and therapeutic applications can be obtained in reasonably large amounts after expression in mammalian cells, milk and plants.
引用
收藏
页码：364 / 370
页数：7
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