Synthesis, characterization and antibacterial screening of some novel 1,2,4-triazine derivatives

被引：60
作者：
Arshad, Mohammad [1 ,2 ]
Bhat, Abdul Roouf [3 ]
Hoi, Kwon Kang [4 ]
Choi, Inho [4 ]
Athar, Fareeda [1 ]
机构：
[1] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India
[2] Aldawadmi Shaqra Univ, Coll Med, Shagra, Saudi Arabia
[3] Sri Pratap Coll, PG Dept Chem, Srinagar 190001, Jammu & Kashmir, India
[4] Yeungnam Univ, Sch Biotechnol, Gyongsan 712749, South Korea
来源：
CHINESE CHEMICAL LETTERS | 2017年 / 28卷 / 07期
关键词：
Synthesis; 1,2,4-Triazine; Antibacterial activity; Toxic effects; M1T-assay; ANTIINFLAMMATORY ACTIVITY; BIOLOGICAL EVALUATION; INDOLE-DERIVATIVES; IN-VITRO; STAPHYLOCOCCUS-AUREUS; HYDRAZONES; ACID; ANTITUMOR; SYSTEMS; IDENTIFICATION;
D O I：
10.1016/j.cclet.2016.12.037
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new series of 1, 2, 4-triazine derivatives possessing indole nucleus were synthesized with an aim to explore their effect on in vitro growth of microorganisms causing microbial infection. In vitro antimicrobial activity was performed against S. aureus, S. epidermidis, P. mirabilis and E. coli using disk diffusion method. The MIC was detected using the double dilution method. The results were compared by calculating percent inhibition area/g of the compounds with the standard drug "Ciprofloxacin". Selected compounds were evaluated for toxic effects using human hepatocellular carcinoma (HepG2) cell line by MTT-assay. Results revealed that some compounds of the series were found to exhibit better activity with less toxicity than Ciprofloxacin (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1559 / 1565
页数：7
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