Fos activation and upregulation of nicotinamide adenine dinucleotide phosphate diaphorase in the rat pituitary by acute capsaicin injection

被引：6
|
作者：
Okere, CO
Higuchi, T
Kaba, H
机构：
[1] Kochi Med Sch, Dept Physiol, Nanko Ku, Kochi 7838505, Japan
[2] Fukui Med Univ, Dept Physiol, Matsuoka, Fukui 9101193, Japan
来源：
NEUROSCIENCE LETTERS | 2000年 / 295卷 / 03期
关键词：
capsaicin; Fos; nicotinamide adenine dinucleotide phosphate-diaphorase; nitric oxide synthase; N-omega-nitro-L-arginine methyl ester; pituitary;
D O I：
10.1016/S0304-3940(00)01609-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study, we examined the effect of acute capsaicin injection on nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d, a histochemical index of nitric oxide, NO, synthase) and Fos expression in the rat pituitary gland. Compared with vehicle, capsaicin significantly activated Fos expression in the anterior and intermediate robes. In addition, capsaicin-treated rats showed a significant upregulation of NADPH-d in the anterior and neural lobes. Pretreatment of the animals with a specific NO synthase inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME), significantly attenuated the capsaicin-induced Fos expression in the anterior and intermediate lobes. These observations suggest that NO is a key regulator of the acute effect of capsaicin on the pituitary gland. (C) 2000 Published by Elsevier Science Ireland Ltd.
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页码：73 / 76
页数：4
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