A linkage study between the GABAAβ2 and GABAAγ2 subunit genes and major psychoses

被引:3
作者
Ambrósio, AM
Kennedy, JL
Macciardi, F
King, N
Azevedo, MH
Oliveira, CR
Pato, CN
机构
[1] Univ Coimbra, Fac Med, Natl Inst Legal Med, Unit Clin & Mol Genet, P-3000213 Coimbra, Portugal
[2] Univ Toronto, Dept Psychiat, Neurogenet Sect, Clarke Inst,Ctr Addict & Mental Hlth, Toronto, ON, Canada
[3] Univ Coimbra, Fac Med, Dept Psychiat, P-3000213 Coimbra, Portugal
[4] Univ Coimbra, Fac Med, Ctr Neurosci, Dept Neurochem, P-3000213 Coimbra, Portugal
[5] SUNY, Upstate Med Univ, Ctr Psychiat & Mol Genet, New York, NY USA
[6] Vet Affairs Med Ctr, Syracuse, NY USA
关键词
D O I
10.1017/S1092852900009913
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Alterations of the gamma-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses. Objective: Restriction fragment length polymorphisms associated with the human gamma-aminobutyric acid type A (GABA(A)) beta(2) and GABA(A) gamma(2) subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses. Methods: Thirty-two schizophrenic families and 25 bipolar families were tested for linkage. Results: Nonparametric linkage (NPL) analysis performed by GENEHUNTER showed no significant NPL scores for both genes in schizophrenia (GABA(A) beta2: NPL narrow=-0.450; NPL broad=-0.808; GABA(A) gamma(2): NPL narrow=0.177; NPL broad=-0.051) or bipotar disorder (GABA(A) beta(2): NPL narrow=0.834; NPL broad=0.783; GABA(A) gamma(2): NPL narrow=-0.159; NPL broad=0.070). Conclusion: Linkage analysis does not support the hypothesis that variants within the GABA(A) beta(2) and GABA(A) gamma(2) genes are significantly linked to major psychoses in a Portuguese population.
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页码:57 / 61
页数:5
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