Hypoandrogenism related to early skin wound healing resistance in rats

被引：4

作者：

Petroianu, A. ^{[1
]}

Veloso, D. F. M. ^{[1
]}

Alberti, L. R. ^{[1
]}

Figueiredo, J. A. ^{[1
]}

Carmo Rodrigues, F. H. O. ^{[1
]}

Carvalho E Carneiro, B. G. M. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil

来源：

ANDROLOGIA | 2010年 / 42卷 / 02期

关键词：

Hypogonadism; orchiectomy; rat; testosterone; wound healing; SEXUAL-MATURITY; TESTOSTERONE; STEROIDS; HORMONES; TESTIS;

D O I：

10.1111/j.1439-0272.2009.00966.x

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

P>The purpose of this study was to verify the effect of testosterone depletion on healing of surgical skin wounds at different ages and post-operative periods. Forty-four Wistar male rats were divided into four groups: Group 1Y (n = 11) - young control, sham-operated rats (30-day old); Group 1A (n = 10) - adult control, sham-operated rats (3 to 4-month old); Group 2Y (n = 10) - young rats after bilateral orchiectomy; and Group 2A (n = 11) - adult rats after bilateral orchiectomy. After 6 months, a linear incision was performed on the dorsal region of the animals. The resistance of the wound healing was measured in a skin fragment using a tensiometer, on the 7th and 21st post-operative days. The wound healing resistance was higher in Group 1Y than in Group 2Y after 7 days (P < 0.05). Wound healing resistance at 21 days was higher than at 7 days in all groups (P < 0.05). Late wound healing resistance was not different between young and adult rats. It is concluded that bilateral orchiectomy diminished the wound healing resistance only in young animals at the 7th post-operative day.

引用

页码：117 / 120

页数：4

共 19 条

[1] Androgen receptor-mediated inhibition of cutaneous wound healing
Ashcroft, GS
Mills, SJ
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (05) : 615 - 624
[2] Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemia
Dockery, F
Bulpitt, CJ
Agarwal, S
Donaldson, M
Rajkumar, C
[J]. CLINICAL SCIENCE, 2003, 104 (02) : 195 - 201
[3] Falkenstein E, 2000, PHARMACOL REV, V52, P513
[4] Congenital absence of the testis in human fetuses and in cryptorchid patients
Favorito, LA
Klojda, CAB
Sampaio, FJB
[J]. INTERNATIONAL JOURNAL OF UROLOGY, 2004, 11 (12) : 1110 - 1113
[5] Fimmel S, 2005, Aging Male, V8, P166, DOI 10.1080/13685530500233847
[6] ANESTHESIA OF ANIMALS FOR BIOMEDICAL-RESEARCH
FLECKNELL, PA
[J]. BRITISH JOURNAL OF ANAESTHESIA, 1993, 71 (06) : 885 - 894
[7] 5α-Dihydrotestosterone (DHT) retards wound closure by inhibiting re-epithelialization
Gilliver, S. C.
Ruckshanthi, J. P. D.
Hardman, M. J.
Zeef, L. A. H.
Ashcroft, G. S.
[J]. JOURNAL OF PATHOLOGY, 2009, 217 (01) : 73 - 82
[8] Androgens modulate the inflammatory response during acute wound healing
Gilliver, SC
Ashworth, JJ
Mills, SJ
Hardman, MJ
Ashcroft, GS
[J]. JOURNAL OF CELL SCIENCE, 2006, 119 (04) : 722 - 732
[9] The hormonal regulation of cutaneous wound healing
Gilliver, Stephen C.
Ashworth, Jason J.
Ashcroft, Gillian S.
[J]. CLINICS IN DERMATOLOGY, 2007, 25 (01) : 56 - 62
[10] Accelerating functional recovery after rat facial nerve injury: Effects of gonadal steroids and electrical stimulation
Hetzler, Laura E. T.
Sharma, Nijee
Tanzer, Lisa
Wurster, Robert D.
Leonetti, John
Marzo, Sam J.
Jones, Kathryn J.
Foecking, Eileen M.
[J]. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2008, 139 (01) : 62 - 67

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