Pt(II) and Ni(II) complexes of octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea derivatives: Synthesis, characterization, physical parameters and biological activity

被引:47
作者
Gemili, Muge [1 ]
Sari, Hayati [2 ]
Ulger, Mahmut [3 ]
Sahin, Ertan [4 ]
Nural, Yahya [1 ]
机构
[1] Mersin Univ, Dept Chem, Fac Pharm, TR-33169 Mersin, Turkey
[2] Gaziosmanpasa Univ, Fac Sci & Arts, Dept Chem, TR-60250 Tokat, Turkey
[3] Mersin Univ, Dept Pharmaceut Microbiol, Fac Pharm, TR-33169 Mersin, Turkey
[4] Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey
关键词
Acid dissociation constant; Biological activity; Pyrrolidine; Thiourea; Complex; Stability constant; IN-VITRO ANTICANCER; CRYSTAL-STRUCTURE; MYCOBACTERIUM-TUBERCULOSIS; ANTIMICROBIAL ACTIVITIES; COPPER(II) COMPLEXES; THIOUREA DERIVATIVES; NICKEL(II) COMPLEXES; ANTIFUNGAL ACTIVITY; AZOMETHINE YLIDES; UREASE INHIBITION;
D O I
10.1016/j.ica.2017.04.026
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
In this study, four novel Pt(II) and Ni(II) complexes of octahydropyrrolo[3,4-c]pyrrole, consisting of pyrrolidine fused to pyrrolidine-2,5-dione, N-benzoylthiourea derivatives were synthesized and their structural characterization was performed by NMR, FT-IR, MS, HRMS and elemental analysis techniques and single crystal X-ray diffraction studies. The octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea compound 3c crystallizes triclinic, with space group P-1. Pt(II) and Ni(II) ions created cis-complexes Pt(II) 4c and Ni (II) 5a forming distorted square-planar structures in orthorhombic space groups Pnma and Pbca, respectively. Furthermore, the ligands behave as bidentate and bind to the metal atom via the S and O atoms. Acid dissociation constants of the ligands were determined by potentiometric titration method in 25% (v/v) acetonitrile-water hydroorganic solvent at 25 +/- 0.1 C-omicron, at an ionic background of 0.1 mol/L of NaCl using the HYPERQUAD computer program and at least three acid dissociation constants were determined for each ligand. Stability constants of Pt(II) and Ni(II) complexes of the ligands were determined by potentiometric titration under the same conditions as stated above. Determination of the stability constant studies show that the ligands tend to form with Pt(II) ion in acidic medium as 1:1 (M:L) and in basic medium as 1:2 (M:L), but the ligands tend to form with Ni(II) ion in both acidic medium and basic medium as 1:2 (M:L). Antibacterial activity of the ligands and their complexes was investigated against S. aureus, B. subtilis, A. hydrophila, E. coli and A. baumannii standard bacterial strains. The ligands and their Pt(II) and Ni(II) complexes exhibited antibacterial activity against mentioned bacterial strains in the range of 62.5-125 mu g/mL, 62.5-250 mu g/mL and 62.5-125 mu g/mL, respectively. Antimycobacterial activity of the compounds was investigated against the M. tuberculosis H37Rv strain. The compounds exhibit antimy-cobacterial activity in the range of 40-80 mu g/mL. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码:88 / 96
页数:9
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