Adult human dental pulp stem cells promote blood-brain barrier permeability through vascular endothelial growth factor-a expression

被引：12
作者：
Winderlich, Joshua N. [1 ,2 ]
Kremer, Karlea L. [1 ,2 ]
Koblar, Simon A. [1 ,2 ,3 ]
机构：
[1] Univ Adelaide, Sch Med, Stroke Res Programme, Adelaide, SA 5005, Australia
[2] Robinson Inst, Ctr Stem Cell Res, Adelaide, SA, Australia
[3] Queen Elizabeth Hosp, Dept Neurol, Woodville, SA 5011, Australia
来源：
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2016年 / 36卷 / 06期
基金：
英国医学研究理事会;
关键词：
Dental pulp stem cells; blood-brain barrier; vascular endothelial growth factor; stromal-derived factor 1; in vitro; MARROW STROMAL CELLS; IN-VITRO; STROKE; INJURY; TRANSPLANTATION; LOCALIZATION; MODULATION; ACTIVATION; OCCLUDIN; THERAPY;
D O I：
10.1177/0271678X15608392
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Stem cell therapy is a promising new treatment option for stroke. Intravascular administration of stem cells is a valid approach as stem cells have been shown to transmigrate the blood-brain barrier. The mechanism that causes this effect has not yet been elucidated. We hypothesized that stem cells would mediate localized discontinuities in the blood-brain barrier, which would allow passage into the brain parenchyma. Here, we demonstrate that adult human dental pulp stem cells express a soluble factor that increases permeability across an in vitro model of the blood-brain barrier. This effect was shown to be the result of vascular endothelial growth factor-a. The effect could be amplified by exposing dental pulp stem cell to stromal-derived factor 1, which stimulates vascular endothelial growth factor-a expression. These findings support the use of dental pulp stem cell in therapy for stroke.
引用
收藏
页码：1087 / 1097
页数：11
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