In vitro characterization of methotrexate-loaded poly(lactic acid) microspheres of different molecular weights

被引：3
作者：
Singh, UV [1 ]
Udupa, N [1 ]
机构：
[1] Kasturba Med Coll, Coll Pharmaceut Sci, Manipal 576119, Karnataka, India
来源：
DRUG DELIVERY | 1998年 / 5卷 / 01期
关键词：
drug release; methotrexate; microspheres; polylactic acid;
D O I：
10.3109/10717549809052028
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Methotrexate-loaded poly(lactic acid) (PLA) microspheres were prepared from three different molecular weight PLAs using the emulsification-solvent evaporation method. The in vitro drug release could be controlled for up to 2 to 3 weeks. The release of the drug was dependent on the molecular weight of the polymer, the fastest release being from microspheres prepared with the lowest molecular weight PLA. This technique allows control of drug release with a single biodegradable homopolymer.
引用
收藏
页码：57 / 61
页数：5
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