The ERG1 K+ Channel and Its Role in Neuronal Health and Disease

被引：17

作者：

Sanchez-Conde, Francisco G. ^{[1
]}

Jimenez-Vazquez, Eric N. ^{[1
]}

Auerbach, David S. ^{[2
]}

Jones, David K. ^{[1
,3
]}

机构：

[1] Univ Michigan, Dept Pharmacol, Med Sch, Ann Arbor, MI USA

[2] SUNY Upstate Med Univ, Dept Pharmacol, Syracuse, NY USA

[3] Univ Michigan, Dept Internal Med, Med Sch, Ann Arbor, MI USA

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2022年 / 15卷

关键词：

ERG1; KCNH2; K(v)11; 1; epilepsy; brain; electrophysiology; LONG-QT-SYNDROME; SUDDEN UNEXPECTED DEATH; HERG POTASSIUM CHANNEL; THYROTROPIN-RELEASING-HORMONE; CENTRAL-NERVOUS-SYSTEM; C-TERMINAL REGION; CRYO-EM STRUCTURE; T-WAVE ALTERNANS; I-KR; CARDIAC REPOLARIZATION;

D O I：

10.3389/fnmol.2022.890368

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1's relationship to the mammalian brain and highlights key questions that have yet to be answered.

引用

页数：19

共 229 条

[41] Modulation of Ether-a-Go-Go Related Gene (ERG) Current Governs Intrinsic Persistent Activity in Rodent Neocortical Pyramidal Cells [J].

Cui, Edward D. ;

Strowbridge, Ben W. .

JOURNAL OF NEUROSCIENCE, 2018, 38 (02) :423-440

[42] A MOLECULAR-BASIS FOR CARDIAC-ARRHYTHMIA - HERG MUTATIONS CAUSE LONG QT SYNDROME [J].

CURRAN, ME ;

SPLAWSKI, I ;

TIMOTHY, KW ;

VINCENT, GM ;

GREEN, ED ;

KEATING, MT .

CELL, 1995, 80 (05) :795-803

[43] Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents [J].

Danielsson, BR ;

Lansdell, K ;

Patmore, L ;

Tomson, T .

EPILEPSY RESEARCH, 2005, 63 (01) :17-25

[44] Phenytoin and phenobarbital inhibit human HERG potassium channels [J].

Danielsson, BR ;

Lansdell, K ;

Patmore, L ;

Tomson, T .

EPILEPSY RESEARCH, 2003, 55 (1-2) :147-157

[45] Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis? [J].

David, Yaron ;

Cacheaux, Luisa P. ;

Ivens, Sebastian ;

Lapilover, Ezequiel ;

Heinemann, Uwe ;

Kaufer, Daniela ;

Friedman, Alon .

JOURNAL OF NEUROSCIENCE, 2009, 29 (34) :10588-10599

[46] Gating mechanism of Kv11.1 (hERG) K+ channels without covalent connection between voltage sensor and pore domains [J].

de la Pea, Pilar ;

Dominguez, Pedro ;

Barros, Francisco .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2018, 470 (03) :517-536

[47] Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain [J].

de la Pena, Pilar ;

Dominguez, Pedro ;

Barros, Francisco .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2018, 470 (07) :1069-1085

[48] Biology of cardiac arrhythmias - Ion channel protein trafficking [J].

Delisle, BP ;

Anson, BD ;

Rajamani, S ;

January, CT .

CIRCULATION RESEARCH, 2004, 94 (11) :1418-1428

[49]

Devinsky O, 2016, LANCET NEUROL, V15, P1075, DOI 10.1016/S1474-4422(16)30158-2

[50] The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues [J].

Dou, Ying ;

Macdonald, Logan C. ;

Wu, Yue ;

Fedida, David .

BIOPHYSICAL JOURNAL, 2017, 113 (09) :1979-1991

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