The ERG1 K+ Channel and Its Role in Neuronal Health and Disease

被引：17

作者：

Sanchez-Conde, Francisco G. ^{[1
]}

Jimenez-Vazquez, Eric N. ^{[1
]}

Auerbach, David S. ^{[2
]}

Jones, David K. ^{[1
,3
]}

机构：

[1] Univ Michigan, Dept Pharmacol, Med Sch, Ann Arbor, MI USA

[2] SUNY Upstate Med Univ, Dept Pharmacol, Syracuse, NY USA

[3] Univ Michigan, Dept Internal Med, Med Sch, Ann Arbor, MI USA

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2022年 / 15卷

关键词：

ERG1; KCNH2; K(v)11; 1; epilepsy; brain; electrophysiology; LONG-QT-SYNDROME; SUDDEN UNEXPECTED DEATH; HERG POTASSIUM CHANNEL; THYROTROPIN-RELEASING-HORMONE; CENTRAL-NERVOUS-SYSTEM; C-TERMINAL REGION; CRYO-EM STRUCTURE; T-WAVE ALTERNANS; I-KR; CARDIAC REPOLARIZATION;

D O I：

10.3389/fnmol.2022.890368

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1's relationship to the mammalian brain and highlights key questions that have yet to be answered.

引用

页数：19

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