An innovation for development of Erlenmeyer-Plochl reaction and synthesis of AT-130 analogous: a new application of continuous-flow method

The development of eco-friendly and efficient processes via one-pot multicomponent synthesis is a very attractive topic. In this work, the Erlenmeyer-Plochl azlactone synthesis was carried out through unique, safe, fast and practical conditions without any catalyst, applying a simple microreactor and gave the corresponding products exclusively. A continuous, first microflow synthesis of N-benzoylglycine carbamide derivatives as AT-130 analogues catalyzed by NafionH@SPIONs was also established successfully.