Association between pre-diabetes, type 2 diabetes and trabecular bone score: The Vietnam Osteoporosis Study

被引：30
作者：
Ho-Pham, Lan T. [1 ,2 ]
Bich Tran [1 ,3 ]
Do, An T. [1 ,2 ]
Nguyen, Tuan V. [1 ,4 ,5 ]
机构：
[1] Ton Duc Thang Univ, Bone & Muscle Res Grp, 19 Nguyen Huu Tho St,Tan Phong Ward,Dist 7, Ho Chi Minh City 700000, Vietnam
[2] Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City, Vietnam
[3] UNSW Sydney, Ctr Big Data Res Hlth, Sydney, NSW, Australia
[4] Univ Technol Sydney, Sch Biomed Engn, Sydney, NSW, Australia
[5] Garvan Inst Med Res, Bone Biol Div, Sydney, NSW, Australia
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2019年 / 155卷
关键词：
Osteoporosis; Type; 2; diabetes; Trabecular bone score; HbA1c; FRACTURE RISK PREDICTION; MINERAL DENSITY; OLDER-ADULTS; TBS; QUALITY; MEN; MICROARCHITECTURE; MELLITUS; WOMEN; METAANALYSIS;
D O I：
10.1016/j.diabres.2019.107790
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aims: Trabecular bone score (TBS) is a surrogate indicator of bone microarchitecture. The present study sought to examine the association between type 2 diabetes (T2D) and trabecular bone score (TBS) in adult Vietnamese men and women. Methods: The study was part of the Vietnam Osteoporosis Study, in which 2702 women and 1398 men aged >= 30 years were recruited from the general community in Ho Chi Minh City. HbA(1c) levels were measured by the ADAMS (TM) A(1c) HA-8160 (Arkray, Kyoto, Japan), and classified into 3 groups: normal if HbA(1c) < 5.7%; pre-diabetes (5.7-6.4%); and diabetes (> 6.4%). TBS was evaluated by iNsight Software, version 2.1 (Medimaps, Merignac, France) on lumbar spine BMD scan (Hologic Horizon). Differences in TBS between diabetic status were analyzed by the multivariable regression model with adjustment for age and body mass index. Results: The prevalence of pre-diabetes and diabetes in men and women was 30.2% and 8.3%, respectively. In women, TBS was lower in pre-diabetes (-0.02; P < 0.001) and diabetes (-0.02; P < 0.001) compared with normal individuals. In men, there was no statistically significant difference in TBS between diabetic status. Moreover, TBS was significantly inversely correlated with HbA(1c) levels in women (P = 0.01), but not in men (P = 0.89). Conclusion: Women, but not men, with type 2 diabetes and pre-diabetes have lower TBS than individuals without diabetes. These data suggest that diabetes and prediabetes are associated with deterioration of bone microarchitecture. (C) 2019 Published by Elsevier B.V.
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页数：8
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