Case-Control Analysis of the Impact of Anemia on Quality of Life in Patients with Cancer: A Qca Study Analysis

被引：9

作者：

Barca-Hernando, Maria ^{[1
]}

Munoz-Martin, Andres J. ^{[2
]}

Rios-Herranz, Eduardo ^{[3
]}

Garcia-Escobar, Ignacio ^{[4
]}

Beato, Carmen ^{[5
]}

Font, Carme ^{[6
]}

Oncala-Sibajas, Estefania ^{[7
]}

Revuelta-Rodriguez, Alfonso ^{[8
]}

Areses, Maria Carmen ^{[9
]}

Rivas-Jimenez, Victor ^{[10
]}

Ballaz-Quincoces, Aitor ^{[11
]}

Moreno-Santos, Maria Angeles ^{[12
]}

Lopez-Saez, Juan-Bosco ^{[13
]}

Gallego-Gallego, Iria ^{[2
]}

Elias-Hernandez, Teresa ^{[1
]}

Asensio-Cruz, Maria Isabel ^{[1
]}

Chasco-Eguilaz, Leyre ^{[11
]}

Garcia-Gonzalez, Gonzalo ^{[2
]}

Estevez-Garcia, Purificacion ^{[14
]}

Marin-Barrera, Lucia ^{[1
]}

Otero-Candelera, Remedios ^{[1
]}

Lopez-Ruz, Sergio ^{[1
]}

Lima-Alvarez, Jorge ^{[15
]}

Sanchez-Diaz, Jose Maria ^{[16
]}

Real-Dominguez, Macarena ^{[17
]}

Borrego-Delgado, Maria Carmen ^{[1
]}

Marin-Romero, Samira ^{[1
]}

Jara-Palomares, Luis ^{[1
]}

机构：

[1] Hosp Virgen Rocio, CIBERES, Med Surg Unit Resp Dis, Resp Dept, Seville 41013, Spain

[2] Hosp Gen Univ Gregorio Maranon, Med Oncol Dept, Madrid 28009, Spain

[3] Hosp Univ Virgen Valme, Hematol & Hemotherapy Dept, Seville 41701, Spain

[4] Hosp Univ Virgen Las Nieves, Med Oncol Dept, Granada 18014, Spain

[5] Hosp Virgen Macarena, Med Oncol Dept, Seville 41009, Spain

[6] DIBAPS Translat Genom & Targeted Therapeut Solid, Hosp Clin, Med Oncol Dept, Barcelona 08036, Spain

[7] Hosp Virgen Macarena, Emergency Dept, Seville 41009, Spain

[8] Hosp Univ Cent Asturias, Med Oncol Dept, Oviedo 33611, Spain

[9] Hosp Orense, Med Oncol Dept, Orense 32616, Spain

[10] Hosp Jerez Frontera, Med Oncol Dept, Cadiz 11407, Spain

[11] Hosp Galdakao Usansolo, Resp Dept, Bizkaia 48960, Spain

[12] Hosp Univ Puerto Real, Med Oncol Dept, Cadiz 11510, Spain

[13] Hosp Univ, Internal Med Unit, Cadiz 11510, Spain

[14] Hosp Virgen Rocio, Med Oncol Dept, Seville 41013, Spain

[15] Hosp Univ Virgen Valme, Resp Dept, Seville 41701, Spain

[16] Hosp Virgen Rocio, Resp Dept, Med Surg Unit Resp Dis, Pharm, Seville 41013, Spain

[17] Univ Malaga, Dept Prevent Med & Publ Hlth, Malaga 29071, Spain

来源：

CANCERS | 2021年 / 13卷 / 11期

关键词：

anaemia; neoplasm; quality of life; EPOETIN-ALPHA; FUNCTIONAL ASSESSMENT; EORTC QLQ-C30; DOUBLE-BLIND; LUNG-CANCER; CHEMOTHERAPY; PREVALENCE; SYMPTOMS; OUTCOMES; FATIGUE;

D O I：

10.3390/cancers13112517

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary The impact of anemia on the quality of life (QoL) in cancer patients has been studied previously; however, the cut-off point used to define anemia differed among studies, thus providing inconsistent results. Therefore, we analysed the clinical impact of anemia on QoL using the same cut-off point for hemoglobin level to define anemia as that used in ESMO clinical practice guidelines. This post-hoc analysis aimed to determine the impact of anemia on QoL in cancer patients through the European Organization for Research and Treatment of Cancer Quality of life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. We found that cancer patients with anemia had significantly worse QoL in clinical terms. In addition, anemic patients had more pronounced symptoms than those in non-anemic patients. Anemia is a common condition in cancer patients and is associated with a wide variety of symptoms that impair quality of life (QoL). However, exactly how anemia affects QoL in cancer patients is unclear because of the inconsistencies in its definition in previous reports. We aimed to examine the clinical impact of anemia on the QoL of cancer patients using specific questionnaires. We performed a post-hoc analysis of a multicenter, prospective, case-control study. We included patients with cancer with (cases) or without (controls) anemia. Participants completed the European Organization for Research and Treatment of Cancer Quality of Life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. Statistically significant and clinically relevant differences in the global health status were examined. From 2015 to 2018, 365 patients were included (90 cases and 275 controls). We found minimally important differences in global health status according to the EORTC QLQ-C30 questionnaire (case vs. controls: 45.6 vs. 58%, respectively; mean difference: -12.4, p < 0.001). Regarding symptoms, cancer patients with anemia had more pronounced symptoms in six out of nine scales in comparison with those without anemia. In conclusion, cancer patients with anemia had a worse QoL both clinically and statistically.

引用

页数：11

共 45 条

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