Asperitaconic acids A-C, antibacterial itaconic acid derivatives produced by a marine-derived fungus of the genus Aspergillus

被引：19

作者：

Ding, Lijian ^{[1
,2
]}

Li, Te ^{[1
,2
]}

Liao, Xiaojian ^{[3
]}

He, Shan ^{[1
,2
]}

Xu, Shihai ^{[3
]}

机构：

[1] Ningbo Univ, Li Dak Sum Yip Yio Chin Kenneth Li Marine Biophar, Ningbo 315211, Zhejiang, Peoples R China

[2] Ningbo Univ, Key Lab Marine Biotechnol Zhejiang Prov, Ningbo 315211, Zhejiang, Peoples R China

[3] Jinan Univ, Coll Chem & Mat Sci, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2018年 / 71卷 / 10期

基金：

中国国家自然科学基金;

关键词：

NIGER; METABOLITES;

D O I：

10.1038/s41429-018-0079-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three new itaconic acid derivatives, asperitaconic acids A-C (1-3), were isolated from the ethyl acetate extracts of the rice fermentation of a marine-derived fungus Aspergillus niger, and asperitaconic acids A-C were characterized by an itaconic acid unit and an alkyl chain moiety. Their structures were established by interpretation of their spectroscopic data including NMR and HRESIMS. Asperitaconic acids A-C exhibited antibacterial effect against Staphylococcus aureus with MIC values of 16-32 mu g/mL, whereas these compounds showed no cytotoxicity against HepG2 and HeLa cancer cell lines.

引用

页码：902 / 904

页数：3

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