Catalyst-Free [3+2] Cycloaddition of Unactivated Imines with Cyclopropenones

被引：20

作者：

Liu, Si-Wei ^{[1
,2
]}

Yuan, Chang ^{[1
]}

Jiang, Xue-Fei ^{[1
]}

Wang, Xian-Xun ^{[2
]}

Cui, Hai-Lei ^{[1
]}

机构：

[1] Chongqing Univ Arts & Sci, Lab Asymmetr Synth, 319 Honghe Ave, Chongqing 402160, Peoples R China

[2] Tonichem Pharmaceut Technol Co Ltd, Huizhou 516008, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 9卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Catalyst-free; Indolizinoindole; Cyclopropenone; Cycloaddition; Heterocyle; BETA-CARBOLINE; INDOLE ALKALOIDS; TRANSFER HYDROGENATION; SCAFFOLD DIVERSITY; CYCLIZATION; DIPHENYLCYCLOPROPENONE; HETEROCYCLES; AZOMETHINES; ANNULATION; CASCADE;

D O I：

10.1002/ajoc.201900630

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a convenient and mild catalyst-free synthesis of structurally diversified indolizinoindoles through [3+2] cycloaddition of dihydro-beta-carbolines and diarylcyclopropenones. Dimethoxydihydroisoquinolines and 3,4-dihydrobenzonaphthyridine can also be used in this process affording corresponding polycyclic N-heterocycles with high molecular complexity.

引用

页码：82 / 85

页数：4

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