Stem Cell Treatment for Alzheimer's Disease

被引：41

作者：

Li, Ming ^{[1
]}

Guo, Kequan ^{[2
]}

Ikehara, Susumu ^{[1
]}

机构：

[1] Kansai Med Univ, Dept Stem Cell Disorders, Hirakata, Osaka 5731010, Japan

[2] Capital Med Univ, Dept Cardiac Surg, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing Anzhen Hosp, Beijing 100029, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 10期

关键词：

Alzheimer's disease; stem cell therapy; oxidative stress; neurodegeneration; AMYLOID-BETA DEPOSITION; BONE MARROW INJECTION; HUMAN ADIPOSE-TISSUE; OXIDATIVE STRESS; AUTOIMMUNE-DISEASES; COGNITIVE FUNCTION; PHYSICAL-ACTIVITY; STROMAL CELLS; CATHEPSIN-B; A-BETA;

D O I：

10.3390/ijms151019226

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) is a progressive and neurodegenerative disorder that induces dementia in older people. It was first reported in 1907 by Alois Alzheimer, who characterized the disease as causing memory loss and cognitive impairment. Pathologic characteristics of AD are beta-amyloid plaques, neurofibrillary tangles and neurodegeneration. Current therapies only target the relief of symptoms using various drugs, and do not cure the disease. Recently, stem cell therapy has been shown to be a potential approach to various diseases, including neurodegenerative disorders, and in this review, we focus on stem cell therapies for AD.

引用

页码：19226 / 19238

页数：13

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