Tripterygium and its extracts for diabetic nephropathy: Efficacy and pharmacological mechanisms

被引：35
作者：
Huang, Wei-jun [1 ]
Liu, Wei-jing [1 ]
Xiao, Yong-hua [2 ]
Zheng, Hui-juan [1 ]
Xiao, Yao [2 ]
Jia, Qi [1 ]
Jiang, Han-xue [1 ]
Zhu, Ze-bing [1 ]
Xia, Chen-hui [1 ]
Han, Xue-ting [1 ]
Sun, Rui-xi [2 ]
Nan, He [2 ]
Feng, Zheng-dong [1 ]
Wang, Shi-dong [2 ]
Zhao, Jin-xi [2 ]
机构：
[1] Beijing Univ Chinese Med, Dongzhimen Hosp, Key Lab Chinese Internal Med, Minist Educ & Beijing, Beijing, Peoples R China
[2] Beijing Univ Chinese Med, Dongzhimen Hosp, Sect Endocrinol & Nephropathy Dept, Beijing, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 121卷
基金：
中国国家自然科学基金;
关键词：
Tripterygium; Efficacy; Pharmacological mechanism; Diabetic nephropathy; WILFORDII HOOK F; OXIDATIVE STRESS; MESENCHYMAL TRANSITION; RHEUMATOID-ARTHRITIS; SIGNALING PATHWAYS; SGLT2; INHIBITORS; RENAL FIBROSIS; KIDNEY-DISEASE; HUMAN GLIOMA; IN-VITRO;
D O I：
10.1016/j.biopha.2019.109599
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Diabetic nephropathy (DN) is a common but intractable diabetic microvascular complication. Tripterygium, a Chinses herb, has been proven to be effective for DN treatment. In this review, the efficacy and pharmacological mechanism of tripterygium and its extracts on DN is elucidated. Tripterygium and its extracts could effectively reduce urine protein and protect renal function. Its pharmacological mechanism involves anti-inflammation, anti-oxidation, anti-glomerulosclerosis and anti-fibrosis, which is achieved by balancing the Th1/Th2 cells, regulating macrophage infiltration, and regulating the following pathways: p38 MAPK, NF-kappa B, TGF-beta, Wnt/beta catenin, Akt and Notch1. Although tripterygium and its extracts may result in some adverse effects, including liver-function damage, gastrointestinal reaction, menstrual disorders, and reproductive problems, they are considered good alternative medicines for DN if used with caution and in the proper manner.
引用
收藏
页数：7
相关论文
共 90 条
  • [1] 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
    Alessi, DR
    Deak, M
    Casamayor, A
    Caudwell, FB
    Morrice, N
    Norman, DG
    Gaffney, P
    Reese, CB
    MacDougall, CN
    Harbison, D
    Ashworth, A
    Bownes, M
    [J]. CURRENT BIOLOGY, 1997, 7 (10) : 776 - 789
  • [2] [Anonymous], 2009, ANN INTERN MED, V151, pw
  • [3] Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation
    Barker, Emily C.
    Kim, Byung-Gyu
    Yoon, Ji Hee
    Tochtrop, Gregory P.
    Letterio, John J.
    Choi, Sung Hee
    [J]. CARCINOGENESIS, 2018, 39 (01) : 36 - 46
  • [4] Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    Brenner, BM
    Cooper, ME
    de Zeeuw, D
    Keane, WF
    Mitch, WE
    Parving, HH
    Remuzzi, G
    Snapinn, SM
    Zhang, ZX
    Shahinfar, S
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (12) : 861 - 869
  • [5] Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)
    Brinker, Anita M.
    Ma, Jun
    Lipsky, Peter E.
    Raskin, Ilya
    [J]. PHYTOCHEMISTRY, 2007, 68 (06) : 732 - 766
  • [6] Kidney toxicity related to herbs and dietary supplements: Online table of case reports. Part 3 of 5 series
    Brown, Amy Christine
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2017, 107 : 502 - 519
  • [7] MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML
    Carter, B. Z.
    Mak, D. H.
    Shi, Y.
    Fidler, J. M.
    Chen, R.
    Ling, X.
    Plunkett, W.
    Andreeff, M.
    [J]. LEUKEMIA, 2012, 26 (03) : 443 - 450
  • [8] Tripterygium wilfordii mitigates hyperglycemia-induced upregulated Wnt/-catenin expression and kidney injury in diabetic rats
    Chang, Baochao
    Chen, Weidong
    Zhang, Yan
    Yang, Ping
    Liu, Lei
    [J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 15 (04) : 3874 - 3882
  • [9] A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
    Chen, Shao-Ru
    Dai, Yan
    Zhao, Jing
    Lin, Ligen
    Wang, Yitao
    Wang, Ying
    [J]. FRONTIERS IN PHARMACOLOGY, 2018, 9
  • [10] Meta-Analysis of Tripterygium Wilfordii Hook F in the Immunosuppressive Treatment of IgA Nephropathy
    Chen, Yi-Zhi
    Gao, Qing
    Zhao, Xue-Zhi
    Chen, Xiang-Mei
    Zhang, Feng
    Chen, Jing
    Xu, Cheng-Gang
    Sun, Lin-Lin
    Mei, Chang-Lin
    [J]. INTERNAL MEDICINE, 2010, 49 (19) : 2049 - 2055
123456789