mRNA-based therapeutics: powerful and versatile tools to combat diseases

被引：406

作者：

Qin, Shugang ^{[1
]}

Tang, Xiaoshan ^{[1
]}

Chen, Yuting ^{[1
]}

Chen, Kepan ^{[1
]}

Fan, Na ^{[1
]}

Xiao, Wen ^{[1
]}

Zheng, Qian ^{[1
]}

Li, Guohong ^{[1
]}

Teng, Yuqing ^{[1
]}

Wu, Min ^{[2
]}

Song, Xiangrong ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc Ctr, Dept Crit Care Med,Frontiers Sci Ctr Dis Related, Chengdu, Peoples R China

[2] Univ North Dakota, Sch Med & Hlth Sci, Dept Biomed Sci, Grand Forks, ND 58203 USA

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2022年 / 7卷 / 01期

关键词：

CHIMERIC ANTIGEN RECEPTOR; LIPID NANOPARTICLE FORMULATIONS; MULTIPLE-SCLEROSIS PATIENTS; CELL STIMULATORY CAPACITY; PLURIPOTENT STEM-CELLS; REVERSE CAP ANALOGS; IN-VITRO SYNTHESIS; ENCODING VEGF-A; CD8(+) T-CELLS; DENDRITIC CELLS;

D O I：

10.1038/s41392-022-01007-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range of incurable diseases. Recent rapid advances in biotechnology and molecular medicine have enabled the production of almost any functional protein/peptide in the human body by introducing mRNA as a vaccine or therapeutic agent. This represents a rising precision medicine field with great promise for preventing and treating many intractable or genetic diseases. In addition, in vitro transcribed mRNA has achieved programmed production, which is more effective, faster in design and production, as well as more flexible and cost-effective than conventional approaches that may offer. Based on these extraordinary advantages, mRNA vaccines have the characteristics of the swiftest response to large-scale outbreaks of infectious diseases, such as the currently devastating pandemic COVID-19. It has always been the scientists' desire to improve the stability, immunogenicity, translation efficiency, and delivery system to achieve efficient and safe delivery of mRNA. Excitingly, these scientific dreams have gradually been realized with the rapid, amazing achievements of molecular biology, RNA technology, vaccinology, and nanotechnology. In this review, we comprehensively describe mRNA-based therapeutics, including their principles, manufacture, application, effects, and shortcomings. We also highlight the importance of mRNA optimization and delivery systems in successful mRNA therapeutics and discuss the key challenges and opportunities in developing these tools into powerful and versatile tools to combat many genetic, infectious, cancer, and other refractory diseases.

引用

页数：35

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