Thiazolidinediones (TZDs) enhance insulin secretory response via GPR40 and adenylate cyclase (AC)

被引：5
作者：
Hwang, Mina [1 ]
Kim, Hyo-Sup [1 ]
Jin, Sang-Man [2 ]
Hur, Kyoo-Yeon [2 ]
Kim, Jae-Hyeon [2 ]
Lee, Moon-Kyu [3 ]
机构：
[1] Sungkyunkwan Univ, Samsung Biomed Res Inst, Div Endocrinol & Metab, Samsung Med Ctr,Sch Med, Seoul, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab, Seoul, South Korea
[3] Eulji Univ, Eulji Univ Hosp, Dept Internal Med, Div Endocrinol & Metab,Uijeongbu Med Ctr, Uijongbu, South Korea
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2021年 / 236卷 / 12期
关键词：
adenylyl cyclase; cAMP; glucolipotoxicity; GPR40; insulin secretion; lobeglitazone; ACTIVATED RECEPTOR-GAMMA; PANCREATIC BETA-CELLS; FREE FATTY-ACIDS; PEROXISOME PROLIFERATOR; PPAR-GAMMA; GENE; GLUCOSE; CAMP; METABOLISM; EXPRESSION;
D O I：
10.1002/jcp.30467
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Thiazolidinediones are synthetic PPAR gamma ligands that enhance insulin sensitivity, and that could increase insulin secretion from beta-cells. However, the functional role and mechanism(s) of action in pancreatic beta-cells have not been investigated in detail.
引用
收藏
页码：8137 / 8147
页数：11
相关论文
共 38 条
[11]   Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion [J].
Dyachok, Oleg ;
Idevall-Hagren, Olof ;
Sagetorp, Jenny ;
Tian, Geng ;
Wuttke, Anne ;
Arrieumerlou, Cecile ;
Akusjarvi, Goran ;
Gylfe, Erik ;
Tengholm, Anders .
CELL METABOLISM, 2008, 8 (01) :26-37
[12]   The biology of peroxisome proliferator -: Activated receptors -: Relationship with lipid metabolism and insulin sensitivity [J].
Ferré, P .
DIABETES, 2004, 53 :S43-S50
[13]   Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor [J].
Gras, Delphine ;
Chanez, Pascal ;
Urbach, Valerie ;
Vachier, Isabelle ;
Godard, Philippe ;
Bonnans, Caroline .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2009, 296 (06) :L970-L978
[14]   Free Fatty Acid Receptors FFAR1 and GPR120 as Novel Therapeutic Targets for Metabolic Disorders [J].
Hara, Takafumi ;
Hirasawa, Akira ;
Ichimura, Atsuhiko ;
Kimura, Ikuo ;
Tsujimoto, Gozoh .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 100 (09) :3594-3601
[15]   Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40 [J].
Itoh, Y ;
Kawamata, Y ;
Harada, M ;
Kobayashi, M ;
Fujii, R ;
Fukusumi, S ;
Ogi, K ;
Hosoya, M ;
Tanaka, Y ;
Uejima, H ;
Tanaka, H ;
Maruyama, M ;
Satoh, R ;
Okubo, S ;
Kizawa, H ;
Komatsu, H ;
Matsumura, F ;
Noguchi, Y ;
Shinobara, T ;
Hinuma, S ;
Fujisawa, Y ;
Fujino, M .
NATURE, 2003, 422 (6928) :173-176
[16]   Rosiglitazone stimulates the release and synthesis of insulin by enhancing GLUT-2, glucokinase and BETA2/NeuroD expression [J].
Kim, Hyo-Sup ;
Noh, Jung-Hyun ;
Hong, Seung-Hyun ;
Hwang, You-Cheol ;
Yang, Tae-Young ;
Lee, Myung-Shik ;
Kim, Kwang-Won ;
Lee, Moon-Kyu .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 367 (03) :623-629
[17]   PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells [J].
Kim, Hyo-Sup ;
Hwang, You-Cheol ;
Koo, Seung-Hoi ;
Park, Kyong Soo ;
Lee, Myung-Shik ;
Kim, Kwang-Won ;
Lee, Moon-Kyu .
PLOS ONE, 2013, 8 (01)
[18]   FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic β-Cells [J].
Kong, Xiangchen ;
Li, Bingfeng ;
Deng, Yushen ;
Ma, Xiaosong .
JOURNAL OF DIABETES RESEARCH, 2019, 2019
[19]   A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs [J].
Kotarsky, K ;
Nilsson, NE ;
Flodgren, E ;
Owman, C ;
Olde, B .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 301 (02) :406-410
[20]   Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet-Induced Metabolic Disease [J].
Lan, Hong ;
Hoos, Lizbeth M. ;
Liu, Li ;
Tetzloffl, Glen ;
Hu, Weiwen ;
Abbondanzo, Susan J. ;
Vassileva, Galya ;
Gustafson, Eric L. ;
Hedrick, Joseph A. ;
Davis, Harry R. .
DIABETES, 2008, 57 (11) :2999-3006
1234