Thiazolidinediones (TZDs) enhance insulin secretory response via GPR40 and adenylate cyclase (AC)

被引：5

作者：

Hwang, Mina ^{[1
]}

Kim, Hyo-Sup ^{[1
]}

Jin, Sang-Man ^{[2
]}

Hur, Kyoo-Yeon ^{[2
]}

Kim, Jae-Hyeon ^{[2
]}

Lee, Moon-Kyu ^{[3
]}

机构：

[1] Sungkyunkwan Univ, Samsung Biomed Res Inst, Div Endocrinol & Metab, Samsung Med Ctr,Sch Med, Seoul, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab, Seoul, South Korea

[3] Eulji Univ, Eulji Univ Hosp, Dept Internal Med, Div Endocrinol & Metab,Uijeongbu Med Ctr, Uijongbu, South Korea

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2021年 / 236卷 / 12期

关键词：

adenylyl cyclase; cAMP; glucolipotoxicity; GPR40; insulin secretion; lobeglitazone; ACTIVATED RECEPTOR-GAMMA; PANCREATIC BETA-CELLS; FREE FATTY-ACIDS; PEROXISOME PROLIFERATOR; PPAR-GAMMA; GENE; GLUCOSE; CAMP; METABOLISM; EXPRESSION;

D O I：

10.1002/jcp.30467

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Thiazolidinediones are synthetic PPAR gamma ligands that enhance insulin sensitivity, and that could increase insulin secretion from beta-cells. However, the functional role and mechanism(s) of action in pancreatic beta-cells have not been investigated in detail.

引用

页码：8137 / 8147

页数：11

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