Novel synthesis of condensed pyridin-2(1H)-one and pyrimidine derivatives

被引：9

作者：

Soliman, AMM ^{[1
]}

Khodairy, A ^{[1
]}

Ahmed, EA ^{[1
]}

机构：

[1] Fac Sci, Dept Chem, Sohag 82524, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2003年 / 178卷 / 04期

关键词：

pyridin-2-ones; pyrimidines; Thorpe-Ziegler cyclization;

D O I：

10.1080/10426500307793

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reaction of N-chloroacetyl derivatives 6-10 with morpholine yielded N-morpholin-1-yl acetyl derivatives 11-15, which were subjected to Thorpe-Zieler cyclization with sodium tent-butoxide to produce the corresponding condensed pyridin-2(1H)-one derivatives 16-20. Treatment of compounds 1, 6-10 with either malononitrile or pchlorobenzylidinemalononitrile in presence of triethylamine, afforded the corresponding pyrimidines 21-25, 27 and pyridine derivative 26 respectively. Moreover compound la teas treated with ethyl isothiocyanoacetate to give the corresponding piprazine derivative 28.

引用

收藏

页码：649 / 665

页数：17

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